Bispectral Index Changes During Flumazenil Be Used For Analepsia After General Anesthesia

Objective:To observe the bispecral index(BIS) changes during fluma-zenil be used for analepsia after general anthesia,and seek the suitable method of fluazenil administration.Methods:Sixty ASA I-II patients scheduled for minor procedures wereandomized into four groups(n=15).In all patients,after combined spinal and epidural anesthesia beginning to operate,propofol given intra-venously to maintain a BIS of 50-55 and infusion was ceased at the end of he procedure. Patients in groupâ… (control group) did not administrate with flumazenil, while those in grupâ…¡,â…¢andâ…£received the first dose of flumazenil 0.1mg,0.2mg and 0.3mg intravenous,respectively.Then, in groupâ…¡â…¢andâ…£,flumazenil O.1mg was followed at 1 min intervals untilo-bserver's assessment of alertness/sedation (OAA/S) scale reached 4. BIS and OAA/S scale were recorded at the end of the procedure and 1,2,3, 5,10,15,20 min after flumazenil admini-stration.Results:When propofol infusion was ceased, BIS was rangedfrom 50 to 55 in all patients.15 min after flumazenil administration, BIS was above 60 in groupâ… ,OAA/S scale reached 3.1 minafter flumazenil administration, BIS was 58 in groupâ…¡, OAA/S scale reached 3. However, 1 min after flumazenil administration,BIS was above 65 in groupâ…¢andâ…£, OAA/S scale reached 4, resuscitation in groupâ…¢andâ…£was significant faster than that ingroupâ…¡(P< 0.05). OAA/S scale reached 4 until flumazenil 0.2 mg was followed in three fourth patient of groupâ…¡.Conclusions:Administrating flumazenil with a first dose of 0.3 mg can reverse sedative effect of the remnants of midazolam and propofol rapidly.