The Expression Of Plasma Visfatin In Components Of Metabolic Syndrome Rate With The Severity Of Coronary

Objective:To study the correlation between plasma visfatin and blood pressure(BP), body mass index (BMI), waist circumference(WC), waist-to-hipratio (WHR), waist-to-heightratio (WHtR), insulin resistance index (HOMA-IR) and Gensini scores by detecting plasma visfatin levels in healthy people and patients with metabolic syndrome.Observing the change of plasma visfatin levels and coronary lesions with the aggregation of MS components.Methods:It is a case-control study.118 patients were enrolled in the study. Group Method:normal control group (48 cases), MS group (42 cases); Then according to the definition of components of MS cumulative score (1-4) were divided into:1 component (10 cases),2 components (18 cases),3 components (24 cases),4 components (18 cases).Fasting plasma visfatin level (by ELISA), fasting insulin (by electorchemiluminescence immunoassay), height, weight, WC, hip, BP, BMI, WHR, WHtR, fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C),apoprotein A(Apo-A), apoprotein B (Apo-B),blood uricemia acid (UA) and Gensini scores were measured in each patient and the HOMA-IR was calculated according to the typical HOMA model. The differences on each parameter were compared among subgroups and groups. The correlations between visfatin and other parameters were investigated by multiple linear stepwise regression analysis. And observing the change of plasma visfatin levels and coronary lesions with the aggregation of MS components.Results:(1) The visfatin level in normal control group (498.48±46.25 ng/ml) were significantly lower than that in MS group (547.00±67.43ng/ml, p<0.01). (2) The visfatin level in MS 1-4 group were 468.99±59.34 ng/ml, 529.97±53.62 ng/ml,537.74±70.04 ng/ml,559.34±65.75 ng/ml. The visfatin level in MS 1 group were significantly lower than that in MS 3 group and MS 4 group (p<0.05). (3) Gensini scores in MS 1-4 group in order of increasing values were 31.60±16.15,42.11±20.00,47.79±17.95, 68.78±31.03. Adjacent group differences were statistically significant (p <0.05). (4) The correlation analysis showed significantly positively correlations between plasma visfatin and BMI, WC, WHR, WHtR, TC, TG, HDL-C, Apo-B, FPG, HOMA-IR and Gensini scores. Multiple linear regression analysis showed that WC, WHtR and Gensini scores were the most significant factor which affect plasma visfatin levels.Conclusion:(1) The plasma visfatin levels significantly higher in patients with MS. Aggregation of MS components increased the degree of coronary stenosis. With the aggregation of MS components, plasma visfatin levels gradually increased. (2) Visfatin is closely related with the degree of coronary stenosis. The higher plasma visfatin levels, the more severe coronary lesions. (3) There was an independent correlation between the levels of plasma visfatin and WC, WHtR, Gensini scores, which imply visfatin may play a role in the pathogenesis of MS and coronary artery disease.