| Purpose:To determine whether addition of gadolinium-enhanced LAVA sequence to MR routine scan imaging is valuable for preoperative assessment of TN stage in patients with primary rectal cancer.; To study the change before and after chemoradiation in tumor microcirculation.Methods:54 patients with primary rectal carcinoma were assessed using MR for Tumour(T) and nodal(N) staging before operation, dynamic enhanced scan were performed in 23 among them,54 non-contrasted and 23 contrasted assessment results of TN staging were compared with those by post-operative pathology respectively;A one-way analysis of variance (ANOVA) was used to compare the enhancing data (maximum concentration value, the maximum slope of the concentration-time curve)in tumor before and after chemoradiation and nomal wall. p=0.05. Results:There is little difference between non-contrasted (64.8%) and contrasted(69.6%) accuracy rate in T staging; in N staging,contrasted (95.4%) is rather than non-contrasted(89.4%); The time of maximum concentration value in tumor before and after chemoradiation and nomal wall is 100s,300s,300s respectively, the maximum slope of the concentration-time curve is in 15s-60s in all the three groups, respectively,2.37±0.65,2.04±0.75, 1.74±0.82, there is statistic difference between rectal cancer and nomal wall., p=0.01. The maximum concentration values in the three goups were not of statistic difference, respectively,,121.49±31.91,121.00±35.68, 103.23±40.55. Conclusion:The addition of gadolinium-enhanced LAVA sequence to MR routine scan imaging is not valuable for preoperative assessment of T stage but valuable for N stage in patients with primary rectal cancer and has diagnostic value; The time of maximum concentration value is later after chemoradiation. the maximum slope of the concentration-time curve has the difference of statistics between rectal cancer and nomal wall. Purpose:The aim of our study is to correlate apparent diffusion coefficients with histologic differentiation and therapy outcome after chemoradiation.Methods:In 54 patients with primary rectal carcinoma, MRI were performed before chemoradiation and operation.,30 patients with definite pathologic type and differentiation degree were grouped into 5, hight differaciated adenoeareinoma (n=5), hight-moderately differentiated adenocarcinoma (n=9), moderately differentiated adenocarcinoma (n=13), moderately-poorly differentiated adenocarcinoma (n=2),poorly differentiated adenocarcinoma (n=1), A one-way analysis of variance (ANOVA) was used to analysis The ADC values among the First three groups. p=0.05; 28 patients undergoing preoperative chemoradiation were grouped into 2, reduced grade (n=18), unreduced grade (n=10). T-test of independent sampler was used to analysis The ADC values among the two groups. Results: The ADC value of hight differaciated adenoeareinoma=1.08±0.126 (mm2/s), The ADC value of hight-moderately differentiated adenocarcinoma=0.966±0.143 (mm 2/s),The ADC value of moderately differentiated adenocarcinoma=0.877+0.087 (mm2/s).There were statistical differences between the hight differaciated adenoeareinoma group and the moderately differentiated adenocarcinoma, p=0.03. And there is the same trend in the three groups. The ADC values are differential in different pathology; The ADC value of reduced grade=0.862±0.113, The ADC value of unreduced grade=0.909±0.142, p=0.561. No significant difference was observed in the two groups'. ADC values. Conclusion:The histopathological differentiation of rectal cancer shows positive correlation with the ADC value. Therefore, DWI with ADC measurement may be a valuable tool for predicting the differentiation of rectal cancer;The therapy outcome after chemoradiation was not significantly related to the ADC value.
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