Expression Of Serum Neuroglobin And Correlation Between Obstructive Sleep Apnea-hypopnea Syndrome And Acute Cerebral Infarction

Objective: To explore the correlation between the regularity of neuroglobin expression and early brain injury because of the chronic intermittent hypoxia in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and acute cerebral infarction.Methods:After they were evaluated by full night polysomnography,40 patients with OSAHS,16 acute cerebral infarction subjects and 16 nomal controls were researched as the objects. First, OSAHS and nomal controls' venous blood were collected at the second moring and acute cerebral infarction subjects' were collected at the 48th hour of the ictus. Second, they were cold-storaged in a refrigerator of - 80℃. Last, Serum levels of neuroglobin were detected by enzyme-linked immunosorbent assay method.Results:Serum levels of neuroglobin in OSAHS group (10.8±5.0)μg/L and acute cerebral infarction group (11.6±3.6)μg/L are remarkably higher than that control group (3.4±1.4)μg/L (both P< 0.01), while serum level of neuroglobin between OSAHS group and acute cerebral infarction is no significant difference (P> 0.05). The concentration of serum neuroglobin in patients with OSAHS are positively correlated with apnea-hypopnea index (r=0.948, P< 0.01), negatively correlated with lowest oxygen saturation (r=-0.800, P< 0.01). there is no a significant relationship between the degree of neuroglobin and cumulative percentage of sleep time with oxygen saturation level below 90% (r=-0.005, P> 0.05).Conclusion:1. Because serum levels of neuroglobin in OSAHS group and ACI group were remarkably high, we confirm to brain injury occurs in patients with OSAHS and acute hypoxia or chronic intermittent hypoxia may induce the brain injury, and neuroglobin might play an important role in the diagnosis of hypoxia brain injury.2. The degree of neuroglobin in OSAHS subject remarkably correlates their pathogenetic condition, and it is positively correlated with apnea-hypopnea index, negatively correlated with lowest oxygen saturation and no a significant relationship between the degree of neuroglobin and cumulative percentage of sleep time with oxygen saturation level below 90%. Therefore Ngb can act as a reference indicator to evaluate the extent of early brain injury and prognosis.