Analysis Of Correlation Between Three-dimensional Ultrasound Parameters And The Number Of Metastastic Celiac Lymph Nodes Of Advanced Gastric Cancer

ObjectiveTo explore the correlation of tumor volume and vascular index (Ⅵ) of advanced gastric cancer with the number of metastastic lymph nodes by three-dimensional ultrasound, and evaluate the correlation between three-dimensional ultrasoundⅥand microvessel density (MVD).Methods55 patients with advanced gastric cancer confirmed by gastroscopic biopsy were taken the measurement of tumor length, the thickness of gastric wall lesions, tumor size, VI values by preoperative three-dimensional ultrasound examination. Then, post-operative specimens were taken CD34 immunohistochemical staining, and microvessel density were counted. According to pathological results, we recorded the number of metastatic lymph nodes. To statistical analyze the correlation between ultrasonic measurement parameters and number of metastastic lymph nodes, as well as theⅥvalue and MVD.ResultsThe number of metastastic lymph nodes in advanced gastric cancer was positively correlated with tumor volume andⅥ(both p<0.001), and this correlation was independent on the pathological type. The number of metastastic lymph nodes had no correlation with the lesion diameter(p=0.332). The number of metastastic lymph nodes was positively correlated with gastric wall thickness (p<0.05).The number of metastastic lymph nodes in the well-differentiated gastric cancer (papillary adenocarcinoma and tubular adenocarcinoma) was positively correlated with gastric wall thickness(p=0.014), while the number of metastasis lymph nodes in the poor-differentiated gastric cancer (poor-differentiated adenocarcinoma, signet ring cell carcinoma, mucinous adenocarcinoma) had no correlation with gastric wall thickness(p=0.336). TheⅥvalue of advanced gastric cancer was 7.635±5.116, and pathological MVD was (31.375±7.767)/×200; advanced gastric cancerⅥvalues and MVD was linear correlation (r= 0.767, p<0.001).ConclusionsThree-dimensional ultrasound offers the possibility for measurement of the preoperative tumor volume of gastric cancer;Ⅵvalue of three-dimensional ultrasound can be used as an indirect and non-invasive method to preoperatively assess gastric cancer vascular richness; three-dimensional ultrasound measurement of volume andⅥvalue provide more information for preoperative evaluation of gastric cancer lymph node metastasis, and guidance for making choices of treatment decision and judgement of prognosis.