Association Of FGFR2 Gene Rs2981582 Single Nucleotide Polymorphism With Hypospadias

ObjectiveTo investigate the association between FGFR2 gene rs2981582 single nucleotide polymorphism and hypospadias in Chinese patients.MethodsTo collect 188 patients and 118 healthy individuals'DNA, design PCR primer.Genotyping of FGFR2 gene rs2515733 performed in 188 patients with and 118 healthy individuals by PCR-RFLPassay respectively.ResultsThe rs2981582 genotypes in the hypospadias patients consisted of homozygote 150(87.77%) C/C,23 (12.23%) C/T, while The genotypes in the controls were composed of 93 (78.81%) C/C,25 (21.19%) C/T. Significant difference was found in the distribution of rs2981582 genotypes between the two groups (X2 =4.396 P=0.028).ConclusionThere may be association between the FGFR2 gene rs2981582 SNP and hypospadias in Chinese northern population.