| Objective:exam the relations between childhood obesity, NAFLD (non-alcoholic fatty liver disease) and other metabolic disorders and study the effects of the oral application of metformin and its integrated treatment with lifestyle intervention in treating NAFLD. Method:using questionnaire to collect data of the adolescents who came to the Children's Hospital, Zhejiang University School of Medicine due to overweight issues during the period between 2004 and 2009, applied body exam and lab exam according to the standards, and tested the data using statistical methods. Result: The average age of the patients is (11.46±2.14), and the prevalence of NAFLD is 67.94%.The prevalence has a dramatc difference as the age increass and also has difference between different genders as well. We divided the obesity adolescents into two groups. Compared with the children who only have slight overweight, children with NAFLD have an obvious higher level in the indicators such as anthropometric indices, serum glutamic pyruvic transaminase (SGPT), blood uric acid, blood lipid level, blood sugar level, serum insulin level and intima-media thickness etc. The prevalence rate of hypertension, liver dysfunction and abnormal glucose metabolism show the similar pattern as well. During the process of follow-up, the metformin treatment shows effects in lowering BMI level and obvious effects were observed in lowering the level of ALT in serum. However the effects in lowering the level of triglyceride were not obvious. Lifestyle intervention also has a certain kind of effects in lowering the BMI of obese adolescents. Conclusion:childhood obesity can cause a series of metabolic disorder. The prevalence of NAFLD among obese children has reached a relatively high level. Measures such as early diagnosis, applying lifestyle at an early stage and taking metformin orally if necessary will have an obvious effect in alleviating symptoms of obesity and relevant metabolic disorders.
|
PDF Full Text Request