Neurodevelopment Outcome Of Children Who Had Isolated Choroid Plexus Cysts Detected Prenatally

Objective:The purpose of this study was to evaluate the neurodevelopment outcome of children who had choroid plexus cysts (CPCs) detected prenatally. Methods:Using a retrospective double cohort design, compare the development of children who had isolated CPCs detected prenatally with a control group of children who had normal prenatal ultrasounds during January 2008 to June 2009 by standardized neurodevelopment measures. Results:There were no differences on demographic variables between the CPCs cohort (n=125) and control cohort (n=119). Suboptimal neurodevelopmental outcome was found in 24.0% of CPCs cohort with is significant higher than control cohort, the risk ratio is 3.86.But most of their suboptimal neurodevelopmental outcome are very mild, which do not need treatment. While the charterers of CPCs, such as solitary or multiple, unilateral or bilateral, big or small and the time CPCs dissolve are not associate with the neurodevelopmental outcome.Conclusion:We conclude that the presence of isolated CPCs on prenatal ultrasound are not likely to be associated with dramatic neurocognitive delays in childhood, but we recommend to follow up the children regularly.