The Experimental Research Of CD44 And Oral Squamous Cell Carcinoma

Objective To investigate the expression of adhesion molecules CD44 in human oral squamous cell carcinoma and to evaluate the relationship between protein level and clinicopathological parameters and the probability of the CD44 using in the gene therapy .Methods Immunohistochemical SABC method detected 65 cases of oral squamous cell carcinoma and 10 cases of normal tissue expression of CD44 protein. Automatic image analyzer using quantitative analysis of the relative content of CD44 (gray). Results Oral squamous cell carcinoma of CD44 protein expression was significantly higher than in normal tissues (P <0.05), CD44 protein in high school, poorly differentiated squamous cell carcinoma group, the average gray value difference between the groups was statistically significant (P <0.01). The higher the degree of tumor differentiation, the lower expression of CD44 protein. CD44 protein expression associated with tumor size, T1, T2, T3 has a statistically significant difference (P <0.01).â…¢, IV period of oral squamous cell CD44 protein expression level is higher than I, II period (P <0.01). With lymph node metastasis of oral squamous cell carcinoma of CD44 protein expression was significantly higher than those without lymph node metastasis (P <0.01). CD44 protein expression and patient's age, sex and tumor location no significant correlation (P> 0.05). Conclusion CD44 protein expression in cancer stem cell markers that may affect the incidence of oral squamous cell carcinoma, development, and their degree of differentiation, clinical stage and lymph node metastasis, which is expected to become the diagnosis and treatment of oral squamous cell carcinoma of indicators.