Intravascular E-Tracking Technology On Carotid Artery Elasticity In Patients With Cerebrovascular Disease Detection And Plasma Homocysteine-related Research

Objective:Tracks the E-Tracking technology examination cerebrovascular disease patient's carotid artery elastic parameter using the echo, and examines the blood plasma homocystein the density, is for the purpose of discussing both's relevance and at the examination cerebrovascular disease early time blood vessel pathological change's clinical value.Method:1.1 The clinical data of cerebrovascular disease Group:November 2008 -2009 12 decided to have 90 cases of cerebrovascular patients were hospital inpatients, the diagnosis consistent with the Fourth National Cerebrovascular Disease Conference revised standard【3】, the first CT or MRI scan confirmed that and according to the concentration of plasma HCY sub-A group (16-30.9μmol / L), B group (31-100μmol / L), C group (> 100μmol / L), each of the 30 cases of male to female ratio of basic equal, the average age (52.8±10.9years). Healthy control group (D group: HCY concentrations of 5-15.9μmol / L): Over the same period to carry out health experience of our hospital, 30 cases, the ratio of men and women are equal, the average age (48.76±6.65 years), had no history of cerebrovascular disease, non-smoking smoking history, high blood lipids, hypertension, diabetes, kidney disease and the recent not oral vitamin B6, B12, folic acid and so on.1.2 Detection Methods1.2.1 plasma homocysteine HCY determination of all the subjects were fasting early morning blood pumping 5ml, centrifugal separation of plasma, using the German Siemens company's analyzers Centaur homocysteine assay using electrochemiluminescence HCY plasma homocysteine concentration (unit:μmol / L).1.2.1 Carotid ultrasonography and carotid artery elasticity index E-Tracking DetectionIn this study, ALOKAα-10 color ultrasound diagnostic apparatus, the patient in supine position to take a quiet state, the access to the common carotid artery long axis view, routine measurement of carotid artery systolic diameter (Ds), intima-media thickness (IMT), systolic Peak flow velocity (PSV), end diastolic velocity (Vd) and resistance index (RI), enter the E-Tracking mode, automatically calculate the changes in blood vessel diameter obtained stress - strain coefficient of elasticity (Ep), hardening parameter (β), compliance (AC), single-point pulse wave velocity (PWVβ), increase the index (AI).1.3 Statistical analysis:All data application SPSS11.5 for statistical analysis and mapping. All measurement data are mean±standard deviation indicated. Between the two groups were used to compare the number of non-paired t test.between Of two-parameter use correlate analysis. Test to P <0.05 considered statistically significant.Results:1. With the control group, cerebral blood vessels A, B group, C group Ds, PSV, RI have no significant difference in disease, cerebrovascular disease A group of IMT was no significant difference; cerebral vascular IMT difference between B group (P <0.05); That vessel C group there was significant IMT difference (P <0.01).2. With the control group, cerebral vascular A group of Ep,βmeasured values were significantly higher (P <0.01), PWVβ, AI control group (P <0.05); AC measurement is lower than the control group (P "0.05). Cerebrovascular among the three groups Ep,β, PWVβ, AC measurement values have significant difference (P <0.05), AI has no statistical difference. 3. Cerebrovascular disease plasma homocysteine concentration and carotid artery elastic parameters Ep,β, PWVβ, AI was negatively correlated with the AC were positively correlated.Conclusion:Cerebrovascular disease in patients with carotid artery atherosclerosis in the event of morphological changes prior to its vascular endothelial function existed injury, cerebrovascular disease in patients with carotid artery elasticity to reduce obviously. Cerebrovascular disease plasma homocysteine concentration and carotid artery elastic parameters Ep,β, PWVβ, AI, AC significantly correlated.