The Effects Of A Small Dose Of Ketamine Or Magnesium Sulfate Preemptive Analgesia On Patients Undergoing Cesaream Section

Objective:To investigate the effects of a small dose of ketamine or magnesium sulfate preemptive analgesia on patients undergoing cesarean section.Method:Eighty patients (ASAâ… ~â…¡) undergoing cesarean section were randomly divided into four groups. Epidural anesthesia was used in all patients. The patients in NaCl group (N group) were given 10 ml saline intravenously, while the patients in ketamine group (K group), in magnesium sulfate group (M group) or in ketamine and magnesium sulfate group (K+M group) were given ketamine 0.3 mg/kg, magnesium sulfate 5 mg/kg or ketamine 0.3 mg/kg and magnesium sulfate 5 mg/kg a minute before skin incision, respectively. All drugs were diluted into 10 ml with saline. All patients recieved patient-controlled epidural analgesia (PCEA) with morphine intravenously for postoperative analgesia. The PCEA solutions contained 0.15% ropivacaine and morphine 5 mg. We investigated systolic blood pressure(SBP), diastolic blood pressure (DBP), heart rate (HR), pulse oxygen saturation(SPO2), patients's consciousness and visceral traction reaction. The visual analog scale (VAS) was assessed at 6 h, 12 h, 18 h and 24 h after the surgery. The patients who has symptoms of nausea, vomiting and itching were also recorded.Results:When babies were delivered, heart rates in N group were higher than the base value and heart rates in K group, M group and K+M group were lower than that in N group. The patients with visceral traction reaction in N group were more than those in K group, M group and K+M group. The mean VAS of patients in N group was higher than that in K group, M group and K+M group at 12 h after surgery. There was no significant difference in MAP, SPO2, patients's consciousness, postoperative analgesic consumption and the incidence of side effects such as nausea, vomiting, itching.Conclusion:A small dose of ketamine or magnesium sulfate has the effects of preemptive analgesia in women having cesarean section. These drugs can inhibit the visceral traction reaction.