Analysis Of Genetic And Behavial Factors On The Occurrence Of Acute Coronary Syndrome

[Objective] To explore the possible behavial factors of acute coronary syndrome and relationship between CFH Y402H polymorphism of Northern Chinese Han population and susceptibility to acute coronary syndrome, and further to explore the interaction with environmental factors to acute coronary syndrome.[Methods] This study consisted of 151 subjects between June 2009 and August 2009 from affiliated hospital of Jining Medical College, All subjects underwented selective coronary angiography or coronary artery CT. Coronary artery disease based on the results of coronary angiography or coronary artery CT that at least one coronary artery diameter reduction of more than 50% and fulfilled the diagnostic criteria of ACC/AHA.84 patients with acute coronary syndrome and 50 controls, and general informations, current disease history, past medical history, related behavial factors were collected. Genomic deoxyribonucleic acid(DNA) was extracted from acute coronary syndrome patients and healthy control subjects, stored in-20℃.The genotype of CFH Y402H was detected by Polymerase chain reaction and restriction fragment length Polymorphism(PCR-RFLP) methods in acute coronary syndrome patients and controls. PCR amplification products was verificated by electrophoresis on agarose gel. Deviation of genotype distribution form Hardy-Weinberg equilibrium was assessed using x2 test in each group. Univariate and multivariate conditional logistic analyses were conducted in the end.[Results] smoking history (P=0.000, OR=4.894, OR 95%CI:2.537～9.441) alcohol drinking history (P=0.008, OR=2.879, OR 95%CI:1.499～5.528) hypertension (P=0.000, OR=4.222, OR 95%CI:2.195～8.123),sports activities (P=0.002, OR=0.333, OR 95%CI:0.188～0.589), salt intake(P=0.007, OR 95%CI:0.287～0.727),character (P=0.000, OR=0.385, OR 95%CI:0.247～0.600) stress of occupations (P=0.015, OR=2.118, OR 95%CI:1.278～3.511) were associated with acute coronary syndrome of Northern Chinese Han population. Smoking history (P=0.010,OR=6.084, OR 95%CI:1.543～23.988), hypertension (P=0.024, OR=2.821, OR 95%CI:1.143～6.595), sports activities (P=0.004, OR=0.297, OR 95%CI:0.130～0.678), personality (P=0.011, OR=0.435, OR 95%CI: 0.229～0.829) were significantly associated with acute coronary syndrome in multivariate conditional logistic analyses after adjusting other factors.[Conclusions] smoking history, hypertension, personality are risk factors of acute coronary syndrome of Northern Chinese Han population. But sports activities is protective factors. CFH Y402H, alcohol drinking, family history, BMI, occupation, educational background, average family income per month, educational background, high salt intake, diet, working hours, hours of sleep, stress of life, social support, stress of occupation, The occurrence of adverse events over the past year may be not associated with acute coronary syndrome.