Genetic Association Of ERa-29T/C Polymorphisms With Chronic Hepatitis B Virus Infection In Gansu Province

AIM To investigation the association between patients with HBV in Gansu province and the polymorphisms of estrogen receptor(ER) alpha gene at the position-29METHODS Polymorphisms of ERa-29 were analyzed in 104 chronic hepatitis B patients,68 patients with HBV-induced cirrhosis and 80 healthy controls by polymerase chain react restriction fragment length Polymorphism(PCR-RFLP) technique.RESULTS The frequencies of TT genotype and T allele of ERa-29 in patients with chronic hepatitis B and HBV-induced cirrhosis were higher than controls,while the frequencies of TC and CC genotype and C allele of ERa-29 in patient with chronic hepatitis B and HBV-induced cirrhosis were lower than controls(P＜0.01).The risk of chronic hepatitis B and HBV-induced cirrhosis occurrence in carriers with T allele were 2.58 and 3.11 folds respectively than that in controls.There was no significant difference in frequencies of allele and genotype of ERa-29 between the chronic hepatitis B group and HBV-induced cirrhosis group(P＞0.05).The frequency of ERa-29 genotypes TT and T allele in patients with HBeAg-negative was markedly higher than that in the HBeAg-positive group(P＜0.05).ERa-29 TT genotype had a increased tendency in the decompensated hepatocirrhosis group,but there was no statistical significance between the compensatory hepatic cirrhosis group and decompensated hepatocirrhosis group(P＞0.05).CONCLUSIONS The polymorphisms in the estrogen receptor alpha gene at the position-29 were associated with HBV infection.