The Effect Of Low Dose Dopamine On Renal Function Of Patients Undergoing Cardiopulmonary Bypass Surgery

Backgrounds:Introduced as a therapeutic drug in the late 1960s,because it induce renal vasodilation,decrease vascular resistance,increase diuresis,natriuresis,enhance GFR and renal blood flow,low dose dopamine (<5ug/Kg/min)became widely used for optimization of renal and splanchnic perfusion.But,these protective effects have been questioned and the side effects have been reported.Objectives:Acute renal dysfunction secondary to cardiac surgery is one of the leading causes for hospital mortality,morbidity and consumption of healthcare resources.Renal blood flow decreases approximately 30% during cardiopulmonary bypass(CPB) accompanied by an increase in renal vascular resitance.The consequent ischaemia impairs both glomerular and tubular functions.Reduce the incidence of renal dysfunction is most important task of doctors.This article is to investigate the effect of low dose dopamine on renal function of patients undergoing CPB surgery.Methods:Twenty-two patients without renal dysfunction were randomized into two groups, experiment group(n=10) received low dose dopamine(2ug/kg/min) by micropump for 12 hours at the beginning of the surgery and control group(n=12) does not, serum creatinine(Cr),blood urine nitregon (BUN) and microalbuminuria(m-Alb) were measured before anesthesia, first day, second day after operation respectively.Results:Neither death nor acute renal dysfunction occurred during or after the surgeries.no significant difference was found in serum creatinine and BUN between the two groups preoperatively or postoperatively, significant difference was found in postoperative microalbuminuria(m-Alb)Conclusion:low dose dopamine has no effect on microalbuminuria(m-Alb) and no renal protection for patients undergoing cardiopulmonary bypass...