The Application Of ¹⁸F-FDG PET(PET/CT)Using SUV 2.5 As A Cut Value To Diagnosis Lung Nodules Of Southeast Asia People: Meta Analysis

ObjectiveTo approach under specific spectrum of disease of lung nodules of Southeast Asia people, if it is suitable to continue following the west nations'standard, which using SUV 2.5 as a cut value. and if it has statistics difference between malignancy patients and benign patients.MethodsThis study use Mata analysis, We searched the Pubmed and CNKI database and picked out the articles about diagnosing lung nodules with FDG PET or PET/CT, the date range from 1-1-2000 to 4-31-2008.We evaluated the quality of the articles according to the standard of diagnotic test recommended by the Cochrane Workshop, then we did the Meta analysis with Review Man 4.2 and MIC software from Cochrane Centre. Finally, we compared the effciency of Southeast Asia people with east nations people witch having lung nodules.Results9 articles entered this Meta-review, the score of articles qualitative range from 5 to 11, the average score was 7.4,62% of full score. sensitive range from 49.1% to 100%, specificity range from 18.2% to 90%,accurate range from 45.5% to 88.3%, PPV range from 34.1% to 95.2,NPV range from 22.2% to 100%,the combine sensitive was 82.7%,specificity was 63.3%;there were not obvious publish bias in the 9 articles, and there was heterology of the 9 articles, the forest figure show RR was 2.34[1.43,3.05],and its 95% confidence interval did not include 1,the chance of malignancy nodules'SUV above 2.5 were more than benign nodules.ConclusionUnder specific spectrum of disease of lung nodules of Southeast Asia people, using SUV 2.5 as a cut value have a effcient value to diagnosis lung nodules.