| Based on the regional ecological features and functions, and dynamic spatial variability of ecosystem, eco-geographical regionalization is divided into regions with relatively unanimous synthetic characteristics and potential productivity, so as to be foundation of rational exploitation, utilization and protection, as well as integrated arrangement and sustainable development.In order to put the scientific concept of development into practice and establish a harmonious society, Shandong government proposed the strategy of "Eco-Shandong", and divide Shandong province into five ecological area in accordance with the regional ecological features and functions, following the principles and methods of eco-geographical regionalization. Afterwards, they put forward the idea of "One Body Two Wings" from the perspective of economic geography to determine the overall layout of the ecological pattern. All of these are the new developments of "Eco-Shandong" strategic concept. However, the division is only based on the natural ecology, social ecology, economical ecology and geo-ecology aspects and not includes the health and disease ecological systems. The status of disease is also a necessary aspect of human ecology and reflects the natural ecology and social ecology. Specifically, the incidence of infectious diseases is a very important ecological index of human health and it is able to report the status and trend of human health. Therefore, it is essential to finish the eco-geographical regionalization of major infectious diseases according to the idea of "Eco-Shandong" and "One Body Two Wings".Average annual incidence of the top ten infectious diseases from 2003 to 2007, is used to be an index for eco-geographical regionalization of Shandong Province. At First, we define regional boundaries of eco-geographical regionalization according to the geographic boundary analysis results. Furthermore, we name the regions combining the eco-geographical regionalization results with the eco-geographical characteristics (such as topography, hydrogeology, groundwater, climate, agricultural climate, plant resources, animal resources, agriculture, forestry, and so on), so as to form a special eco-geographical regionalization of a certain infectious disease.Main research results:1 Shandong province can be divided into four regions according to the geographical boundary analysis of average annual incidence of HFRS from 2003 to 2007: Western plain area with low incidence of HFRS, Northern plain area-Central and southern hilly area with high incidence of HFRS, Eastern plain hilly region with moderate HFRS incidence, Jiaodong low hilly areas with low incidence.2 Shandong province can be divided into four regions according to the geographical boundary analysis of average annual incidence of viral hepatitis from 2003 to 2007: Northwest Plain areas with moderate incidence of viral hepatitis , Central mountain hilly region - Western plains - the Yellow River Delta region with a high incidence of viral hepatitis, Central southern mountain hilly region - Jiaolai Plain area with moderate incidence of viral hepatitis, Northern low hilly coastal area in Jiaozhou with high incidence of viral hepatitis.3 Shandong province can be divided into four regions according to the geographical boundary analysis of average annual incidence of dysentery from 2003 to 2007: Northern plain areas with low incidence of dysentery, Central mountain hilly region - Yellow River Delta area with high incidence of dysentery, Western and southern plain area-Southeast hilly area with low incidence of dysentery, Jiaobei low hilly area with a high incidence of dysentery. 4 Shandong province can be divided into three regions according to the geographical boundary analysis of average annual incidence of infectious diarrhea from 2003 to 2007: Southwest plains lake district with a high incidence of infectious diarrhea, Northwestern plain area-Northern coastal plain-Central southern mountain hilly area with a low incidence of infectious diarrhea, Jiaobei low hilly areas with a high incidence of infectious diarrhea.5. Shandong province can be divided into four regions according to the geographical boundary analysis of average annual incidence of tuberculosis from 2003 to 2007: Northwest Plains region - the Yellow River Delta with a high incidence of tuberculosis, Southwest plain Lakes region- Southern Mountain hilly area with a high incidence of tuberculosis, Central plain and hilly region - Northern coastal hilly area with moderate incidence of tuberculosis, Eastern coastal hilly area with moderate incidence of tuberculosis.6. Shandong province can be divided into four regions according to the geographical boundary analysis of average annual incidence of mumps from 2003 to 2007: western plain areas with low incidence of mumps, central zoster Rouge area with a high incidence of mumps, central hilly area - southern plain hilly area - north low hilly ribbon area with low incidence of mumps, eastern hilly coastal areas with moderate incidence of mumps.7 Shandong province can be divided into three regions according to the geographical boundary analysis of average annual incidence of measles from 2003 to 2007: northwest Plain area with high incidence of measles, Southwest plain Lakes area with high incidence of measles, part of western plain area - central southern mountain hilly area- the Yellow River Delta - eastern hilly area of Jiaozhou with low incidence of measles.8. Shandong province can be divided into four regions according to the geographical boundary analysis of average annual incidence of scarlet fever from 2003 to 2007: Northwest plains in the north of the Yellow River - the Yellow River delta area with low incidence of scarlet fever, Central hilly area with high incidence of scarlet fever, Southwestern plain lake area in the south of Yellow River - Central southern mountain hilly areas with low incidence of scarlet fever, Jiaodong coastal mountain hilly area with a high incidence of scarlet fever.9. Shandong province can be divided into four regions according to the geographical boundary analysis of average annual incidence of gonorrhea from 2003 to 2007: Northwestern plains-Northern coastal plain area with low incidence of gonorrhea, Central mountain hilly area with a high incidence of gonorrhea, Southwestern plain Lakes area-Central Southern Mountain hilly area with low incidence of gonorrhea, Jiaodong low hilly areas with a high incidence of gonorrhea.10 Shandong province can be divided into three regions according to the geographical boundary analysis of average annual incidence of gonorrhea from 2003 to 2007: Capital economic circle area with high incidence of syphilis, Northwest Plains area-Southwest Plains Lakes-Northern coastal plain area - South Mountain hilly area with low incidence of syphilis, Jiaodong hilly coast areas with high incidence of syphilis.Conclusions:1. Eco-geographical regionalization can be conducted based on Spatial distributions of average annual incidence of the top ten infectious diseases in Shandong Province ,which show significant spatial heterogeneity and structural characteristics,2. Eco-geographical regionalization of different infectious diseases display diverse characteristics, yet similar infectious diseases (such as Enteric Infectious Diseases) share similar regions, which reflects ecology and geography may be important factors influencing incidence of infectious diseases.3. Eco-geographical regionalization maps of infectious diseases will be helpful in further study on ecological influencing factors, establishing regional prevention measurements of infectious diseases, and optimizing regional arrangement of health.4. It is a feasible method of eco-geographical regionalization of infectious diseases, which first determines the eco-geographical regions of infectious diseases according to the geographic boundary analysis based on spatial heterogeneity of disease, then combines the indexes of socio-economic geography and physical geography, and finally defines and delineates the eco-geographical regions of infectious diseases.5. The Combination of Wombling method in geographic boundary analysis and contour map of disease level is an effective way in conducting eco-geographical regionalization of infectious diseases, suitable for spatial continuous data.
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