Analysis On The Correlativity Between Ambulatory Aterial Stiffness Index And Target Organ Damage In Male Patients With Primary Hypertension

Objective:To observe the ambulatory arterial stiffness index (AASI)in male patients with primary hypertention,Analyze the relationship between AASI and hypertention-associated target organ damage characters such as 24-h urinary albumin excretion,left ventricular mass index(LVMI),carotid-femoral pulse wave velocity(C-FPWV) and carotid atherosclerotic plaque.Meanwhile,Analyze the relationship between AASI and riskfactors of cardiovascular diseases(CVD) such as age,elevated blood pressure, obesity,dyslipidemiaand glycometabolism disorders.Methods:102 male patients with primary hypertention were chosen..The relationship between AASI and risk factors of cardiovascular disease along with hypertention-associated target organ damage characters was analyzed with Pearson correlation analysis.The linear regression relationship between AASI and target organ damage characters such as LVMI,C-FPWV and 24-h urinary albumin excretion was analyzed with Bivariate linear regression analysis.The difference of AASI between control group and target-organ damage group such as left ventricular hypertrophy group,arteriosclerosis group,microalbuminuria group and arteriothickness group with t-tset..The independent correlativity relationship between AASI and target-organ damage characters such as LVMI,C-FPWV,24-h urinary albumin excretion and carotid atherosclerotic plaque was analyzed with multiple linear regression and multiple logistic regression analysis.Results:1 There was direct correlationship between AASI and CVD risk factors such as age,central aortic pressure,Triglyceride,24-h mean systolic blood pressure and 24-hr mean pulse pressure,as well as target organ damage characters such as LVMI,C-FPWV and 24-h urinary albumin excretion.(P＜0.05)2 There was exact linear relationship between AASI and C-FPWV (R=0.476;P=0.000),LVMI(R=77.44;P=0.0004) as well as 24-h urinary albumin excretion(R=294.461;P＜0.0001).3 AASI of microalbuminuria group was higher than that of non-microalbuminuria group(0.55 versus 0.38,P=0.000).AASI of carotid atherosclerosis group was higher than that of non- carotid abnormalities group(0.52 versus 0.38,P=0.006).AASI of left ventricular hypertrophy group was higher than that of non- left ventricular hypertrophy group(0.55 versus 0.39,P=0.000).AASI of arteriosclerosis group was higher than that of non- arteriosclerosis group(0.56 versus 0.42,P=0.000)4 multiple linear regression analysis demonstrated that there was independent correlativity between AASI and C-FPWV,LVMI as well as and 24-h urinary albumin excretion P＜0.05.multiple Logistic regression analysis demonstrated that there was independent correlativity between AASI and carotid atherosclerosis P＜0.05。Conclusion:1.AASI is a new index of arterial stiffness.2.Increased AASI is predictive of target organ damage in primary hypertension.