| OBJECTIVE To investigate the condition of out-patient's antibiotic drug use and adverse drug reaction report in part hospitals of Tongling. So as to improve rational use of antibiotic drugs and decrease occurrence of adverse drug reaction.METHODS Outpatient's prescriptions were selected randomly in clinical west-drugstore's prescriptions in three principal hospitals in Tongling from October 2007 to September 2008.The outpatient's prescriptions were undergone statistical analyses in aspects of usage of antibiotics, percentages of single use and combined use of antibiotics, route of administration, etc , and the use rationality of antibiotics were analysed; ADR reports reported at the same time by three hospitals were collected and those about ADR caused by antibiotics were analysed. Part of clinic doctors were sampled randomly to fill out questionnaires abut rational use of antibacterial drugs and recognition of ADRM.RESULTS Among the total 43680 prescriptions investigated in the three hospitals,19733(45.18%) were antibacterial drugs prescriptions;and the average cost of each prescription was 96.8 yuan, 41.06% of which was expended in antibacterial drugs. Of these antibacterial drugs, 40.05% was cephalosporins and it dominated the first among all the antibacterial drugs, 8562(43.39%) were combined use of antibacterial drugs and the two kinds of antibacterial prescriptions took the lead. 7254(36.76%) was intravenous injection. 2421(12.27%) was unreasonable use of antibacterial prescriptions.Among all the ADR reports, 266 were reported from hospital A and hospital B(hospital C didn't have ADR reports). Of which, 24(9.02%) were reported from clinic staffs. 227(85.34%) ADR were caused by antibacterial drugs, 108(47.58%) of them caused by cephalosporins took the lead.Investigation of reasonable use of antibacterial drugs showed, among the three hospitals, higher professional doctors were better than those lowers in understanding reasonable use of drugs. Of 80 investigated doctors, nobody had acquired full marks and only 36(45%) had got better scores.Investigation of recognition degree on ADRM showed, only 49% of the clinic doctors who had been investigated understood the definition of ADR;78% believed that drugs had some adverse reaction after marketing; 88% had the experience of ADR, only 18(19%) had ever reported ADR but only 3(16.67%) reported ADR voluntarily; 39% clinic doctors unknew the ADR report process, 36% unknew how to fill in the ADR report table, 22% didn't know the aim of collecting ADR reports in our country. 18% staff didn't know the possibility to cause ADR after using antibacterial drugs.CONCLUSION Percentages of the use of antibacterial drugs are high in Hospitals in Tongling, and abuse liability and irrationality in the route of administration and medication are noted. Percentages of the drug combination are high and some of which is improper. Some clinic staffs did not understand rational use of antibacterial drugs enough and need to enhance training. Also, some clinic staffs did not recognize the perniciousness of ADR adequately. Clinic staffs should improve the consciousness of ADRM and the monitoring of ADR should be strengthened. |
