| Objective:Aimed to observe the effect of Nourishing spleen Replenishing Qi and Blood Fang combined with the chemotherapy of FOLFOX4 on immune function in patients with colorectal cancer after operation(Deficiencies of Qi and Blood).To investigate the short-term curative effect and the TCM's function of reducing toxicity and increasing effect on chemotherapy of using Nourishing spleen Replenishing Qi and Blood Fang combined with the chemotherapy of FOLFOX4.And provide clinical edvidence and theoretical basis for the research of TCM combined with chemotherapy treatment of patients with colorectal cancer after operation.Methods:40 cases with Colorectal Cancer after operation randomly divided into two groups,the treatment group(Nourishing spleen Replenishing Qi and Blood Fang combined with the chemotherapy of FOLFOX4) with 20 cases,the control group(chemotherapy alone FOLFOX4)with 20 cases.Treated with FOLFOX4 conventional chemotherapy,and 14 days as a course of continuous observation for 4 cycles.Chemotherapy treatment group with Nourishing spleen Replenishing Qi and Blood Fang for oral taken once a day in the interim period day.compared two groups in changes in immune function,quality of life,the improvement of symptoms Chinese situation.Results:①Comparison in Immunal function:CD3+ and CD4+ significantly increased in treatment group(P＜0.01);CD3+ increased(P＜0.05)and CD4+ had no significant difference in the control group;There is significant difference in both groups after treatment(P＜0.05).CD8+ singnificantly decreased in treatment group(P＜0.01),and had no significant change in the control group;however there is significant difference in both groups after treatment(P＜0.05).NK cell and CD4+/CD8+ significantly increased in treatment group(P＜0.01);in the control group there is no singnificant difference;but there is significant difference in both groups after treatment(P＜0.01).Both treatment group and control group had no significant change in IgA(P＞0.05);Both treatment group and control group significantly increased in IgG(P＜0.01),but there is no significant difference in both groups after treatment(P＞0.05).IgM significantly increased in treatment group(P＜0.01);and had no significant change in the control group(P＞0.05);but there is significant difference in both groups after treatment(P＜0.05).②Comparison in Quality of life:there is significant improvement in Quality of life in the treatment group compaired with the comtrol group(P＜0.05).③Comparison in Symptoms TCM improvement:After treatment,in the treatment group,8 cases were marked effect,11 cases were effect,1 case had no effect,the total effective rate up 95%;in the control group,2 cases were marked effect,8 cases were effect,10 cases had no effect,the total effective rate only 50%,there is significant difference(P＜0.01).④Comparison in the change of KPS Score: After treatment,the treatment group and the control group had no significant difference in the change of KPS Score(P＞0.05).⑤Comparison in the change of Body Weight:After treatment,in the treatment group,16 cases increased in Body Weight,3 cases had no significant change,1 case decreased;in the control group,5 cases increased in Body Weight,7 cases had no significant change,8 cases decreased,there is significant difference(P＜0.05).⑥Comparison in the change of CEA and CA199:There is no significant differece in two groups before treatment(P＞0.05);after treatment,in the treatment group,CEA had no significant change,CA199 singnificantly decreased(P＜0.05);but there is no significant difference in two groups after treatment(P＞0.05).⑦Comparison of Safety:there is no singificant difference in safety in two groups(P＞0.05).Conclusion:①Nourishing spleen Replenishing Qi and Blood Fang combined with the chemotherapy of FOLFOX4 can improve immune function of patients with colorectal cancer after operation.②Nourishing spleen Replenishing Qi and Blood Fang combined with the chemotherapy of FOLFOX4 can improve the TCM clinical symptoms and the life quality of patients.
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