The Clinic Analysis Of 84 Cases Diagnosed Of Primary Gastrointestinal Lymphoma

Purpose:To discuss the diagnosis and the best choice of therapeutic regiment,the prognostic influence of clinic classifications and histopathologic features,and possible prognostic factors of the primary gastrointestinal lymphoma.Methods:We retrospectively analysed 84 patients diagnosed PGIL and treated in our hospital between 2002 and 2008.The diagnosis, therapeutic regiment,the clinic pathological features,histological classifications and prognostic factors were evaluated.Results:84 patients diagnosed PGIL,including 44 cases of primary gastric lymphoma,39 cases of primary intestinal lymphoma,and 1 case of lymphoma originated in both stomach and small intestine.The average age of the patients was 49 years old.The male-to-female ratio was 1.9:1. Most of the patients distributed in the area from 40 to 60 years old. Diseased region:In the cases of gastric lymphoma,most originated in the sinuses ventriculi and corpora ventriculi.In the cases of intestinal lymphoma,most originated in the ileocecus and terminal ileum.The abdominal pain was the most common symptom.It accounted for 76.2 percent.Hemorrhage of digestive tract was accounted for 41.7%. Anorexia was accounted for 59.5%.Asarcia was accounted for 52.4%. Histological and cytological classification:In 44 cases of gastric lymphoma,39 cases originated in B cells,1 cases was marked in both B and T cells,4 cases were not mentioned cell origination;2 cases of DLBCL,31 cases of MALT,1 case of MALT with megacell metaplasia,1 case of mixed type of megacell and cellule,3 cases of diffusive B-cell type,1 case of part of DLBCL conversion,5 cases with no typing.In 40 cases of intestinal lymphoma(including 1 case originated in both stomach and small intestine),28 cases originated in B cells,4 cases originated in T cells,4 cases were not mentioned cell origination;1 cases of DLBCL,17 cases of MALT,1 cases of diffusive small B-cell type,1 case of part of DLBCL conversion,3 cases of other types,17 cases with no typing. Clinic stage aging:In 44 gastric lymphoma,stage of disease was IE for 20Patients,ⅡE for 13,ⅢE for 2,ⅣE for 9.In 40 cases of intestinal lymphoma,stage of disease wasⅠE for 13 Patients,ⅡE for 16,ⅢE for 3,ⅣE for 8.Prognosis:The primary gastric lymphoma had better prognosis than the primary intestinal lymphoma.Histological features,clinic classification and therapeutic regiment had the influence to the prognosis.Conclusion:1.The prevalence of gastrointestinal lymphoma in middle-age and old man is the highest.The symptoms of the PGIL are non-specific.2.In gastric lymphoma,the sinuses ventriculi and corpora ventriculi are the most common sites.In the intestinal lymphoma,the ileocecus and terminal ileum are the most common site.3.The primary gastric lymphoma has better prognosis than the primary intestinal lymphoma.The cell origination of PGIL has the possible correlation with the prognosis.The prognosis of the T cells origination is worse.4.The prognosis of the abnormalβ2-MG team is worse than the normalβ2-MG team.5.The clinic classification has the correlation with the prognosis.The prognosis of earlier stage(stageⅠE andⅡE) is better than stageⅢE and stageⅣE.6.The prognosis of operation combined post-operative chemotherapy is better than simply operation or chemotherapy.It can prolong the survival course.