Expression And Its Significance Of PDGF-BB,VEGF-C In Human Colon Carcinoma

ObjectiveTo investigate the relationship between the expression of PDGF-BB,VEGF-C and the clinicopathologic parameters in colon cancer;and to investigate the difference of VEGF-C,PDGF-BB expression in primary and lymph nodes metastatic carcinoma.Methods50 colon carcinomas, 30 matestatic lymph nodes and 15 peritumoral normal tissues obtained in operation were stained by SP immunohistochemical staining. PDGF-BB, VEGF-C expression in colon carcinoma tissues, matestatic lymph nodes ,and peritumoral normal tissues was observed.ResultsThe positive expression rate(50%) of VEGF-C in colon carcinoma was significantly higher than in peritumoral normal tissues(P<0.05); VEGF-C expression correlated with depth of invasion(P<0.05), lymph node metastasis(P<0.05),On the other hand, correlations were nil with regard to gender of the patients,tumor sizes and cellular differentiation(P>0.05). The expression rate(54%) of PDGF-BB in colon carcinoma was also higher than in peritumoral normal tissues(P<0.05); PDGF-BB expression correlated with depth of invasion(P<0.05), However, had nothing to do with gender of the patients,tumor sizes,cellular differentiation and lymph nod metastasis (P>0.05). There was positive correlation between the expression of PDGF-BB and VEGF-C(P<0.05). PDGF-BB,VEGF-C levels measured in the metastatic lesions were higher than the levels observed in the same patient's primary colon tumors, but not statistically significant(VEGF-C:P>0.05;PDGF-BB:P>0.05).ConclusionsThe expression of VEGF-C which was up-regulating in colon carcinoma concerned with the invasion and lymph node metastasis of colon caicinoma. There was not a difference between VEGF-C staining in primary and lymph node metastatic tumors. The expression of PDGF-BB which was up-regulating in colon carcinoma related with the invasion of colon caicinoma. There was not a difference between PDGF-BB staining in primary and lymph node metastatic tumors. The expression of PDGF-BB and VEGF-C have a positive correlation in colon carcinoma.