| Objective: To evaluate the effect of preoperative interventional chemotherapy (PICT)on the expression of focal adhesion kinase (FAK)andα-catenin in patients with advanced colorectal carcinoma(ACC)and their relationship with clinicopathologic characteristics of ACC.Methods: The expression of FAK and a-catenin in ACC were detected using immunhistochemical technique in 34 patients which were treated with radical operation after interventional chemotherapy(PICT group) ,which were compared with them detected using immunhistochemical technique and western blotting in 42 patients which were only treated with radical operation (control group).Result:The positive expression rates of FAK was 71.4% in control group,which was significantly higher than that in PICT group (35.3%, P〈0.05), but there was no significant difference between control group (45.2%) and PICT group (29.4%)about the positive expression rates ofα-catenin (P>0.05).The positive expression rates ofα-catenin and FAK had a significant difference in TNM stage,the depth of invasion and lymph node metastasis in ACC(P<0.05).The positive expression rates ofα-catenin were also related to tumor differentiation status(P<0.05). There was no statistical correlation between FAK andα-catenin expressions in tumor(P>0.05).Conclusion :The positive expression rates ofα-catenin and FAK were related to invasion /metastasis of ACC . PICT may can reduce the expression of FAK in ACC,by which inhibit operative and postoperative invasion /metastasis of tumor cells,but the effect of it on the expression ofα-catenin was no statistical significance. |
