A Clinical Study On Carotid Elasticity In Patients With Diabetic Retinopathy By E-Tracking Technique

ObjectiveThe study is to detect carotid elasticity in patients with diabetic retinopathy by E-Tracking technique,and to detect the haemodynamic parameter of the central retinal artery(CRA),in order to evaluate its clinical value in detecting diabetic vasculopathy in early time.Materials and methods90 patients with typeⅡdiabetes and 30 healthy volunteers underwent ultrasonography(US) examination(ALOKAα—10).All US examination were performed with the patients in supine position,and to survery the systolic diameter of the carotid artery(Ds),Intima media thickness(IMT),peak systolic velocity(PSV),Resistanceindex (RI) in long axis view of carotid artery,Then entered the E-Tracking mode,calculated the variation of internal vascular diameter,obtained the pressure strain elastic modulus(Ep),stiffness parameter(β),arterial compliance(AC),pulse wave conducting velocity(PWVβ),augmentation index(AI).Measured the peak systolic velocity(Vs),the end diastolic velocity(Vd) and resistanceindex(RI) of central retinal artery in both eyes.Statistical analysis:Statistical analyses was performed with SPSS11.5 software system.All data were expressed as mean±SD.When compared means among many groups we adopted t-test with post hoc comparison.Pearson's correlation analysis were performed to display certain relations.Findings with a P value less than 0.05 was considered as statistically significant.Results1.Comparing with the control group,the Ds,PSV,RI have no obvious difference among the group A,B,C.Group A IMT have no obvious difference;Group B IMT have obvious difference(P＜0.05);Group C IMT have obvious difference(P＜0.01).2.Comparing with the control group,Ep,βof group A is higher than the control group(P＜0.01),PWVβ,AI is higher than the control group(P＜0.05);AC is lower than the control group(P＜0.05).The Ep,β,PWVβ,AC among every diabetic groups have statistic difference(P＜0.05),AI has no statistic difference.3.Comparing with the control group,group A Vs,Vd is obvious lower than the control group(P＜0.01),the RI is higher than the control group obviously(P＜0.01).The Vs,Vd,RI have statistic difference(P＜0.05) among every diabetic group.4.The haemodynamic parameter Vs,Vd of the central retinal artery(CRA) in diabetes group are negative correlated with Ep,β,PWVβ,AI,and positive correlated with AC;The haemodynamic parameter RI of the central retinal artery(CRA) in diabetes group are positive correlated with Ep,β,PWVβ,AI,and negative correlated with AC.ConclusionIn patients with typeⅡdiabetes,before the morphology changes in sclerotic carotid artery are observed,the damage of endothelium function already exists.The elasticity of carotid artery in patients with diabetic retinopathy is more lower obviously.The Vs,Vd and RI of central retinal artery are obviously correlated with Ep,β,PWVβ,AI,AC of carotid artery.