Allium Stalk Extract Combat Myocardial Ischemia In Coronary Heart Disease Clinical And Experimental Research

Object:1,To observe the effect of clinical symptoms,signs,electrocardiogram,blood rheology,blood lipids and other indicators by Allium Stalk extract of myocardial ischemia in coronary heart disease Patients,Research on Allium Stalk extract treatment of coronary heart disease the effect of myocardial ischemia and its mechanism.2,To observe the effect of Energy metabolism and microcirculation to swines of myocardial ischemia,To investigate its role in myocardial protection and mechanism.3,By Research of clinical and experiment,from one side to clarify the initial "barrier yang" and the relationship between coronary heart disease,Yang method for providing a theoretical basis for prevention and treatment of coronary heart disease.Method:The first part of clinical research:Select July 2005-August 2007 First Hospital of Wuhan City,Hubei Province,Chinese medicine hospital out-patient clinics and medical wards of the heart in patients with coronary heart disease 100 cases of myocardial ischemia,according to TCM diagnostic criteria for evidence-based classification,and random divided into treatment group and 50 cases of the control group.Two groups of patients before treatment and nitrate medicine out all five days of drugs observed in conventional treatment of the two groups remains unchanged,the labor to maintain the status quo remains unchanged,during treatment ask Patientslow-fat low-salt diet,regular exercise. Jiuxin pill drug selection of the control group treatment,each 10, 2 times daily,Allium Stalk extract from Wuhan City in the provision of Integrated Traditional and Western Medicine Hospital Pharmacy, 2 each,2 times daily,for a four-week course of treatment, observation of drug effect after 2 weeks.Observe the safety,the treatment of clinical symptoms and signs before and after the score, ECG changes,hemorheology and blood lipid were measured.The second part of experimental research:The 24 pigs were randomly divided into blank model group,sham-operated group,Allium Stalk extract group trimetazidine group 4 groups 6.Through the balloon occluder 60min anterior descending coronary artery preparation of porcine myocardial ischemiamodel,such as after the fourth day to be the volume of normal saline,Allium Stalk extract,trimetazidine treatment of 28 days,and then line ¹³N-NH₃,¹⁸F-FDG PET/CT detection of myocardial perfusion imaging.Of left ventricular myocardial SPECT image analysis of Allium Stalk extract on myocardial energy metabolism and microcirculation,as well as the correlation between the two.Results:The first part of clinical research:clinical observation study, the two treatment groups in patients with age,sex and disease were not significantly different(P＞0.05),two groups of cases to improve symptoms of coronary heart disease have a certain role in the treatment of Allium Stalk extract The total effective rate 93.75%,control group Jiuxin pill group the total effective rate 91.67%(P＞0.05);after treatment to improve the overall efficiency ECG no significant differences(P＞0.05);stallion group treated extract maximum platelet aggregation the rate of whole blood viscosity,plasma viscosity,hematocrit,fibrinogen,CRP decreased Jiuxin pill group and after treatment showed no significant difference(P＞0.05),decreased LDL lipid levels,HDL significantly increased,and Jiuxin pill comparison group after treatment had significantly difference(P＜0.05).The second part of experimental research:gaps in the model group, in 54 myocardial segments,there are segments of myocardial viability for the 28(51.85%);sham-operated group,¹³N-NH₃ PET myocardial perfusion imaging with ¹⁸F-FDG PET myocardial metabolic imaging of the same 54 myocardial segments that were normal; stallion extract group,in 54 myocardial segments,there are segments of myocardial viability for the 44(81.48%);trimetazidine group,54 myocardial segments,there are segments of myocardial viability for the 41(75.93%).Allium Stalk extract group trimetazidine group and the blank model group dynamic number of myocardial segments were significantly different(P＜0.01); stallion extract group and trimetazidine group dynamic myocardial segments no significant difference between the number of(P＞0.05).Conclusion:1,Allium Stalk extract treatment of myocardial ischemia in coronary heart disease is safe and effective:Allium Stalk extract used in the treatment of coronary heart disease clinical safety,and efficacy of certain side effects.In the evaluation of clinical efficacy,although the efficiency of the two groups there was no significant difference,but Allium Stalk extract a higher degree of ease the symptoms of angina pectoris in patients with coronary heart disease(including angina attack frequency,duration,degree of pain and ease the way),to improve the performance of EGG of myocardial ischemia.2,Allium Stalk extract by regulating lipid metabolism,prevention and treatment of coronary heart disease:the pulse coronary atherosclerosis is the pathological basis of the occurrence and development,and abnormal lipid metabolism is atherosclerosis of vein important reason for regulation of lipid metabolism is abnormal coronary heart disease prevention effective means to extract stallion can significantly lower blood lipid levels,and anti-atherosclerosis,delaying the process of coronary heart disease.3,Allium Stalk extract can promote myocardial ischemia myocardial ischemia to improve microcirculation:very light blue extract can significantly reduce the maximum platelet aggregation rate,whole blood viscosity,plasma viscosity,hematocrit,fibrinogen,as well as significant improvement in ischemic myocardial blood flow, promote blood circulation to improve myocardial ischemia.4,Allium Stalk extract can optimize energy metabolism, anti-oxidative damage,the protection of myocardial cells: ischemic myocardium due to ischemia and hypoxia caused by abnormal cell energymetabolism,resulting in a large number of oxygen free radical injury of myocardial cells,the study shows that Allium Stalk extract can optimize myocardial cells energy metabolism, protection of porcine myocardial ischemia. 5,"Yang barrier" is an important cause of myocardial ischemia, "Tung-yang," the treatment of myocardial ischemia is an important tool,it is worth in-depth study:clinical and experimental studies have shown that:The Yang of Chinese medicine is safe and effective treatment of myocardial ischemia,various types of myocardial ischemia in patients with coronary heart disease have a better effect on the occurrence of myocardial ischemia and "yang barrier" is closely related to both yang barrier may lead to myocardial ischemia is the initiating factor,or it may be other after myocardial ischemia causes the major clinical manifestations.And trimetazidine does not affect hemodynamics different stallion extracts can affect not only hemodynamics,but also improve myocardial energy metabolism,reflects the traditional Chinese medicine,multi-system,the efficacy advantage of multi-targets. Therefore,the timely and effective "yang" is to improve the treatment of myocardial ischemia in an effective way,it is worth in-depth study.