| ObjectivesTo observe the effects of Xianling Gubao and miacalcic ampoule and only miacatcic ampoule on clinical symptoms,signs of rheumatoid arthritis,discuss the different influence of the two groups affect the prognosis of patients with RA.Methods60 cases according with diagnosis both with western medicine and TCM were divided into Observation group and Control group(n=30, respectively).The observation group were applied with miacalcic ampoule,Xianling Gubao and methotrexate.The use of miacalcic ampoute is 50IU per time intramuscular injection,once a day in the first week;50IU per time every other day in the second week;50IU per week in the three week to twenty four weeks.With Xianling Gubao 3 tablets per time,twice a day.And a weekly oral methotrexate(MTX) 10mg per time,every week,with folic acid tablets weekly 5mg treatment(24 hours after takeing MTX).The control group were applied with miacalcic ampoule and methotrexate.The use of miacalcic ampoule is same as above.And a weekly oral methotrexate(MTX) 10mg per time,every week,and folic acid tablets weekly 5mg treatment.Six-weeks' treatment made up 1 course,and observe twenty four weeks.Both groups underwent TCM symptoms scoring and efficacy evaluation after treatment,along with grading disease condition and Society of American College of Rheumatology (ACR) efficacy evaluation,to investigate the extent of score improvement before and after treatment and make comparison between groups.Results1.On ACR therapeutic effects:ACR efficacy evaluation results showed that the observation group had 21 effective and 9 without effect(total effective rate:70.00%,and for Control group,they were respectively 6 effective and 24 with no effect(with the total effect:20.00%).ACR comparison between two groups showed significant difference(P＜0.01).2.On clinical symptoms:There were no differeces between the two groups on symptoms as joint pressing pain,swelling before treatment(P＞0.05).After treatment The two groups showed significant difference in comparisons(P＞0.05).3.Effects on Laboratory indicators:Before treatment,there were no differeces between the two groups on laboratory indicators as ESR and CRP(P＞0.05).After treatment,the ESR and CRP of tuo groups decreased obviously,the significant difference was exist (P＜0.01).4.Effects on disease grading:Among 30 cases in Control group,11 cases made up the 36.67%mild severity;16 made up 53.33%moderate and 3 made up the 10.00%severe condition.And for Treatment group, 13 out of total 30 cases took up 43.33%mild condition;14 made up 46.67%moderate and 3 for the 10.00%severe cases.Between group comparison showed no singnificant difference(P＞0.05).5.Total TeN syndromes score:No significant differece was seen in comparison between the two groups before treatment(P＞0.05),and significance lied in that after treatment——both scores declined obviously than that before(P＜0.05).Moreover,a between groups comparison demonstrated significant difference(P＜0.05).6.On total TCM therapeutic effects:In Treatment group,condition of 4 cases were clinically controlled,rest cases showed 14 obvious efficay and 8 effectiveness as well as 4 cases noneffectiveness, the total effective rate was 86.67%,and statistical differences were observed in comparison with Control group,as the latter group had 2 case controlled,10 obvious effective,2 of efficacy and 16 ineffective(total effective rate was 46.670%)(P＜0.05).7.On Safety:During treatment,both the blood cells analysis and liver and kidney function were in normal range.In observation group there were 3 cases appeared dizziness,face flushing,but soon alleviate voluntarily.4 cases in Control group appeared local scratching with tolerance and disappeared in several minutes.No cases quited during treatment.ConclusionsThe combination of Xianling Gubao and Miacalcic ampoule can improve the prognosis of patients with RA greatly,along without adverse reactions and side effects.
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