The Impact Of Hypoxia Inducible Factor -1 In Rats After Ischemia-reperfusion Injury In Acute Inflammatory Response

Objective:To observe the hypoxia-inducible factor-1 on myocardial ischemia-reperfusion injury in acute inflammatory response after impact.Methods:24 rats of clean grade were randomly divided into 3 groups:acyl ethylene dimethyl glycine(DMOG) group and the control group,sham-operated group,8 in each group.TMOG group,at ischemia and reperfusion injury model to set up before the 24h intraperitoneal injection 20ug / g DMOG;control group,at ischemia and reperfusion injury model set up to 24h before intraperitoneal injection of normal saline 0.5ml; In addition to the sham-operated group,the other 2 groups through the left anterior descending coronary artery ligation and 60 min,then release the 180 min set up myocardial ischemia reperfusion injury in animal models;sham-operated group did not left anterior descending coronary artery ligation.Three experimental rats at the end of all mining right atrial blood,separation of serum,the serum intercellular adhesion molecule-1(ICAM-1),Interleukin -8(IL-8) expression levels;killed animals removed heart,measured in rat myocardial tissue hypoxia inducible factor -1 of the mRNA.Results:DMOG group of hypoxia-inducible factor-1 of mRNA expression than the control group increased significantly(P＜0.05);DMOG serum levels of ICAM-1 and IL-8 expression level of significantly lower(P＜0.05).Conclusion:The hypoxia-inducible factor -1 through inhibiting ICAM,IL-8 synthesis,reduced neutrophil infiltration,thus improving myocardial ischemia-reperfusion injury of myocardial ischemia-reperfusion injury has important protective effects for the prevention and treatment myocardial ischemia-reperfusion injury has provided a new treatment ideas.