The D-dimer Change In Human Acute Pancreatitis And Its Relative Factors

Objective: The aim of our study was to investigate the role of the D-dimer in human acute pancreatitis and its relation to the severity of the disease and the hypertriglyceriemia.Method: Plasma concentration of the D-dimer was measured in 31 patients with mild acute pancreatitis(MAP), 30 patients with severe acute pancreatitis (SAP)and 30 normal people as the control group. The results of routine laboratory tests, 48hRanson and 24hAPACHEâ…¡scores were all recorded. We attempted to find a relationship between the D-dimer level and the results of routine laboratory tests, 48hRanson scores, 24hAPACHEâ…¡scores. 61 AP patients were divided into high TG group and low TG group based on the level of the triglyceride in the serum. We also attempted to find a relationship between the D-dimer level and the triglyceride.Results: (1)Compared with the control group, plasma concentration of the D-dimer was much higher in MAP(P=0.029)and SAP patients(P=0.000). The D-dimer level in the SAP group was higher than the MAP group(P=0.000).(2)The rise in the D-dimer level was directly related to the 48 hRanson(P=0.000)and 24 hAPACHEâ…¡scores(P=0.000). (3)The rise in the D-dimer level was directly related to the leukocyte count, blood glucose, creatinine, prothrombin time and partial thromboplastin time(P<0.05)and inversely related to the hematocrit, albumin and calcium(P<0.05). (4)By comparation of the control group ,serum concentration of the triglyceride was much higher in MAP(P=0.450)and SAP patients(P=0.010)(.5)Plasma concentration of the D-dimer was much higher in the high TG group than low TG group.(P=0.020). The rise in the D-dimer level was directly related to the triglyceride in serum(P=0.000).Conclusion: Plasma concentration of the D-dimer rises in AP patients, the D-dimer level is related to the disease severity. The rise of D-dimer level is likely to be related with triglyceride in serum.