Progress In Cyclooxygenase-2,Vascular Endothelial Growth Factors-C/Vascular Endothelial Growth Factors Receptor-3 And Lymphatic Metastasis Of Lung Cancer

Lymphatic metastasis is one of the route of metastasis in lung cancer. Vascular endothelial growth factors(VEGFs) and their receptors (VEGFRs) play important roles during this processes of lymphatic metastasis. Particularly, VEGFR-3 and its ligand VEGF-C play crucial roles in promoting lymphatic vascular growth. Recent researches have demonstrated that there is a positive correlation between cyclooxygenase-2 and lymphatic metastasis of lung cancer. It would be a new method of targeted therapy in lymphatic metastasis of lung cancer to target cyclooxygenase-2,VEGF-C/VEGFR-3.