| The study of relationship between the levels of maternal serum and cord blood adiponection and insulin in fetal growth restriction0bjective:To explore the roles and the effect of insulin and adiponectin on the fetal growth.Methods:sixty-three mothers and newborn infants between Aug.2007 and Det.2008 in our hospital obstetrics .Samples of maternal blood and matched umbllical cord blood were collected at time of delivery from twety-first of mothers and newborns with nomal birth weight (control group) , twety-first pairs with fetal growth restriction(FGR group) and twety-first pairs with macrosomia (macrosomia group).serum insulin were measured by radiommunoassay(RIA), serum adiponectin were measured by The enzyme-linked immunosorbent assay.Results (1) The age and the delivery mode between FGR, macrosomia and control groups had no significantly different(P >0.05),The gestational weeks in FGR groups was significantly lower than macrosomia and control groups(P<0.05)(37.71±3.00 weeks vs39.09±3.04 weeks vs 40.02±3.14 weeks). (2) The birth gestational weeks and newborn birth weight in FGR newborn groups was significantly lower than macrosomia and control groups (37.71±3.00weeks vs39.09±3.04 weeks vs 40.02±3.14 weeks, 2211.9±236.1g vs 3302.4±389.3g vs 4161.9±136.0g ,P<0.05), The newborn body length, newborn birth weight/ body length ratio and head circumference in FGR newborn groups was significantly lower than macrosomia and control groups (48.09±1.34cm vs 51.52±1.03cm vs 50.57±0.68cm,45.91±3.88g/cm vs80.62±1.60g/cm vs 65.23±7.27g/cm,31.04±1.47cm vs 35.05±1.43cm vs 32.43±2.16cm, P<0.05) .(3).The levels of maternal serum adiponectin and insulin in FGR group were2.9±1.3ng/ml,12.8±10.0uIU/ml respectively;adiponectin and insulin levels of fetal serum in this group were 31.5±12.7ng/ml,10.6±6.3uIU/ml respectively .(4).In macrosomia group The levels of maternal serum adiponectin and insulin were 23.2±18.0ng/ml,12.7±7.3uIU/ml respectively;in fetal serum that were 40.1±10.4ng/ml,14.9±8.5uIU/ml respectively.(5).In control group The levels of matermal serum adiponectin and insulin were 12.5±10.2ng/ml,13.2±5.0uIU/ml respectively;in fetal serum that were 37.8±6.7ng/ml,11.9±4.3uIU/ml respectively. (6). The levels of matermal serum adiponectin in FGR groups was significantly lower than macrosomia and control groups(P<0.01), The level of cord blood adiponectin in FGR groups was significantly lower than macrosomia and control groups(P<0.05);in the three group the levels of maternal serum adiponectin was significantly lower than that of fetal levels(P<0.01).(7).the newborn birth weight in the FGRgroups was significantly lower than macrosomia and control groups.(2211.9±236.1g vs 3302.4±389.3g vs 4161.9±136.0g ,P<0.01) ;the placental weight in the FGRgroups was significantly lower than macrosomia and control groups(435.2±10.6g vs 538.6±11.0g vs 682.5±13.7g ,P<0.01) .(8).The levels of matermal serum insulin in between FGR, macrosomia and control groups had no significantly different(P >0.05) ; The level of cord blood insulin in between FGR, macrosomia and control groups had no significantly different(P >0.05) . (9). in the three group the levels of maternal serum adiponectin and insulin had no positively correlated (r=-0.074,r=0.189,r=-0.054,P>0.05);The level of cord blood adiponectin were negitively significantly correlated with insulin(r=-0.536,r=-0.462,r=-0.434,P<0.05); In the three group the level of maternal serum adiponectin and the cord blood adiponectin had no positively correlated (r=0.214,P>0.05); in the three group the levels of maternal serum insulin and the cord blood insulin had no positively correlated (r=0.243,P>0.05).(10) In the three group The level of cord blood adiponectin were positively correlated with their birth weight,placental weight,head circumference and body length, birth weight/ body length ratio (r=0.283,r=0.259, r=0.325, r=0.278,P<0. 05); the level of cord blood insulin had no positively correlated with their birth weight,placental weight, head circumference and body length, birth weight/ body length ratio (r=0.067,r=0.036,r=0.033,r=0.113, r=0.062, P>0.05); in the three group The level of maternal serum adiponectin had no positively correlated with their birth weight,placental weight,head circumference and body length, birth weight/ body length ratio (r=0.139,r=0.365,r=0.270,r=0.243, r=-0.140,P>0.05); The level of maternal serum insulin had no positively correlated with their birth weight,placental weight, head circumference and body length, birth weight/ body length ratio (r=0.006,r=0.047,r=-0.005,r=-0.014, r=0.06,P>0.05).Conclusions Cord blood adiponectin and insulin play an important roles in adjust fetus growth and development,they can be regarded as one of the clinical indexes to evaluate fetus growth and development and fat depot condition .The matermal serum and cord blood adiponectin source had different , adiponectin cannot pass through the placenta. The adiponectin had correlated with the fetal growth, The decrease level of cord blood adiponectin may be one of the index of predict the fetal growth restriction.The study on the relationship and role of adiponectin, cholesterol and triglyceride in the fetus growth and developmentObjective: To explore the roles of cholesterol and triglyceride in the fetus growth and development,to study on the relationship between adiponectin, cholesterol and triglyceride.Methods: sixty-three mothers and newborn infants between Aug.2007 and Det.2008 in our hospital obstetrics .Samples of maternal blood and matched umbllical cord blood were collected at time of delivery from twety-first of mothers and newborns with normal birth weight (control group),twety-first pairs with fetal growth restriction(FGR group) and twety-first pairs with macrosomia (macrosomia group). According to the maternal serum TG and TC to analysed the correlation between the adiponectin ,TG,TC and fetus growth and development.Results: (1)The levels of matermal serum cholesterol in FGR groups was significantly lower than macrosomia and control groups(5.14±1.05vs5.78±0.92vs 5.89±1.18,P<0.05), The level of matermal serum cholesterol in macrosomia and control groups had no significance difference(5.78±0.92 vs 5.89±1.18,P>0.05).(2)The levels of matermal serum triglyceride in FGR groups was significantly lower than macrosomia and control groups(2.64±0.93 vs 3.35±1.16 vs 2.91±0.87,P<0.05), The level of matermal serum cholesterol in FGR and control groups had no significance difference(2.64±0.93 vs2.91±0.87, P>0.05).(3) In the three group the level of maternal serum triglyceride and the maternal serum adiponectin had no positively correlated (r=0.228,r=-0.304,r=-0.117,P>0.05), In the three group the level of maternal serum cholesterol and the maternal serum adiponectin had no positively correlated (r=0.041,r=-0.433,r=0.174,P>0.05)。(4) In the three group the level of maternal serum triglyceride and the cord blood adiponectin had no positively correlated(r=-0226,r=0.078,r=-0.390,P>0.05),In the three group the level of maternal serum cholesterol and the cord blood adiponectin had no positively correlated (r=-0.249,r=-0.255,r=-0.077,P>0.05)。(5) In the three group The level of maternal serum triglyceride were positively correlated with cholesterol (r=0.376,P<0.01)。(6) In the three group The level of maternal serum triglyceride and cholesterol were positively correlated with their birth weight,placental weight,head circumference and body length, birth weight/ body length ratio (r=0.285,r=0.350,r=0.298,r=0.250, r=0.289,r=0.308,P<0.05)。Conclusion: the expectant mother should reasonable intake the hyperlipoidsfood,avoid hypernutrition and hypoalimentation,reduc the low birth weight infant and large for date infant rate , decrease risk of the development of metabolic syndrome in in the future life.
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