Deng Cared That The Analgetic Paste Treats Coronary Disease Angina Pectoris The Clinical Research

BackgroundCoronary heart disease is a serious human health hazards of the common cardiovascular diseases,the disease morbidity and mortality are high,and showed an upward trend year after year.How to effectively take the initiative to combat coronary heart disease in the medical field is an important topic,ora -l and intravenous drug therapy of coronary heart disease has a long history of interventional therapy,surgical bypass treatment in the rapid improvement in blood supply,such as to alleviate angina pectoris made great progress.A -lthough intervention after clopidogrel treatment,such as strengthening the anti-platelet aggregation drugs,treatment,intervention and then there are still narrow,the occurrence of cardiovascular events,such as inadequate.H -ave reported in the literature,for half a year abroad,bare metal stentresten -osis rate is reported as 20%～40%.Drugs can reduce coronary stent restenosis rate of occurrence,with the large-scale randomized,controlled trials conduct -ed,there is found to have higher long-term restenosis rate,and the security issue has attracted increasing attention.CABG better improvement in patients with severe coronary artery disease prognosis,clinical practice for many y -ears the undisputed show that timely and effective reconstruction of coronary revascularization surgery can reduce mortality and alleviate angina symptoms, improve prognosis and quality of life.However,the drawbacks of surgery has become a widespread concern.Therefore,to find a fast real-time effects,long duration,side effects of treatment has also become a research hotspot in recent years.In recent years,foreign countries take the lead in the use of transdermal administration of nitroglycerin for treatment of coronary heart disease better efficacy,and external application of Chinese medicine treatment of coronary heart disease national research has also made some progress.Transdermal delivery of Chinese medicine treatment of coronary heart disease more than external to the meridian theory,Chinese medicine may be external skin,pore opening,leading directly to disease Acupoints absorption.Division I since 2000,Professor Deng Tietao in,under the guidance of the use of analgesic cream Guanxin Tang 50 cases of coronary heart disease treatment,and achieved a good clinical effect,treat -ment group was 88.5%,compared with the control group were significantly d -Afferent(P＜0.01).Therefore,effective in the initial clinical,based on the research requirements of modern TDDS,analgesic cream for Tang Guanxin characteristics,influencing factors and mechanism of absorption was studied in order to reveal the objective,scientific content,will not only expand Chinese Medicine the development of space;At the same time,pre-clinical in accordance with the requirements of new drugs in clinical trials,certainly may be good economic and social benefits.PurposeResearch on the subject in the past,based on the observation of Tang analgesic cream Guanxin clinical efficacy of the treatment of angina pectoris, ECG,heart color Doppler ultrasound,serum protein markers high-sensitivity CRP,endothelin(ET),nitric oxide(NO) and so on,to clarify Guanxin Tang paste mechanism of pain may be related to inhibition of inflammatory cytokines, diastolic coronary blood vessels,improving vascular endothelial function.F -or Chinese medicine,to provide theoretical guidance to combat angina.MethodChoice of 88 cases of angina pectoris patients were randomly divided into treatment group and control group,two groups are given conventional antiplatelet, anticoagulant,lipid,anti-angina pectoris,and symptomatic treat -ment,anti-angina drugs,includingβblock agents,nitrates and calcium a -ntagonists,if combined with diseases such as hypertension and diabetes,and depending on the joint application of step-down condition,such as the treat -ment of hypoglycemic.Treatment group in the drug treatment given to the basis of the above,the increase in pain with Tang Guanxin cream paste,respectively in the smell of mutton is a cave temple and the Arab-Israeli daily 2 patches. Both groups were,respectively,to observe the effect of disease,ECG effects, changes in points of TCM Syndrome symptoms efficacy observed before and after treatment at the same time high sensitivity CRP,nitric oxide(NO),endothelin (ET) and other indicators of change.And for blood,urine,stool routine,liver (ALT),renal(BUN,Cr) targets security features,such as detection.Results and DiscussionThe two groups after treatment in the clinical efficacy,effect of TCM syndrome,blood stasis compared with before treatment were significantly dif -ferent(P＜0.05),the treatment group in the reduction of ET,to increase NO significantly than the control group(P＜0.05 ),in the reduction of hs-CRP than the control group no significant difference between the two groups were no adverse reactions to blood,urine,stool routine,liver(ALT),renal(BUN, Cr) security features such as no significant impact.Tang Guanxin analgesic cream to be effective prevention and treatment of coronary heart disease angina pectoris;its mechanism may be related to inhibition of inflammatory cytokines,diastolic coronary blood vessels and improve endothelial function and so on.