Urodynamic Changes In The Rat Model With Chronic Nonbacterial Prostatic Inflammation

Purpose To observe the gradual development of prostatic inflammation and concomitant urodynamic changes of Wistar rats.Discuss the relationship between Chronic nonbacterial prostatitis(CP) and voiding dysfunction.Material and Methods A total of 50 adult male Wistar rats were randomly divided into 5 groups,10 each.Except for sham operation group,4 other groups were castrated under sterile condition.One day after operation,the rats were separately injected estradiol benzoate(0.25 mg/kg·d^-1,s.c.) solved in peanut oil for 15 days and 30 days and estradiol benzoate(0.125 mg/kg·d^-1,s.c.) for 30 days,the equivalent peanut oil as model control,what's more,the sham operation group were given normal saline.After the last treatment for one day,the urodynamical recordings and histopathological analysis were done.Results Estrogen treatment can induce prostatic inflammation in the rats and different degree of inflammation and lymphocytic infiltration was found in prostate. Comparison with sham operation group and model control group,of the 30 days E₂ 0.25mg/kg group,voiding threshold pressure was significantly increased,while bladder capacity and compliance were significantly decreased(P＜0.05),no significant change was observed in the other groups(P＞0.05).Conclusions Castration and estradiol benzoate can induce prostatic inflammation.Elevated estrogen concentration was essential for the gradual development of prostatic inflammation.The chronic nonbacterial prostatitis model exist urodynamic changes which developed in association with glandular inflammation.