| Objective In order to study the expression ofⅢbeta-tubulin in ovarian carcinoma,and theⅢbeta-tubulin probably become a factor of taxol drug resistance and prognosis in ovarian carcinoma.Methods 60 primary ovarian carcinoma cases divided into two groups:drug-resistance and sensitive.TheⅢbeta-tubulin expression was examined by immunohistochemical method in ovarian carcinoma.Results①Positive expression ofⅢbeta-tubulin in malignant was higher than ones in benign and normal tissues(P＜0.05).②The staining intensity forⅢbeta-tubulin was related to clinical stage,histological grade and lymphatic node metastasis(P＜0.05).③The positive rates ofⅢbeta-tubulin in valid cases was less than invalid cases(P＜0.05).Conclusion TheⅢbeta-tubulin may play an important role in taxol drug-resistance mechanisms,The detection ofⅢbeta-tubulin may predict the curative effect of chemotherapy,it is helpful to make reasonable chemotherapy scheme and evaluate the prognosis in ovarian carcinoma.It could probably be as a marker of taxol drug resistance.
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