The Research Progression Of Portal Hypertension Treat By Conbined Treatment Of Traditional Chinese Medicine And Western Meditreatment

Hepatocirrhosis is world disease,and it is frequently encountered disease in China,too.There are different about cirrhosis cause all over the world,in China,cirrhosis cause mainly are virus hepatitides(hepatitis),schistosomiasis,alcoholism,etc.Causes of kinds of cirrhosis all may induce inflammation necrosis.Hepatic cell inflammation,necrosis must relate to fiberr egeneration,then to fibrosis.dMain cells of cirrhosis is hepatic star cell(HSC) in last years.The effect of HSC on portal hypertensive has been more thought.After HSC activation;smooth muscle actin in cells more express,which increase contractility of HSC.High or low of portal vein is related to its inhibition and flow.Contractition of HSC reguladtes portal vein inhibition and flow.For many years it has been accepted that hepatic stellate cells(HSCs) play a key role in hepatic fibrosis.Accumulating evidence from in vitro and in vivo studies suggests that stellate cells are also involved in the regulation of the liver microcirculation and portal hypertension.Activated hepatic stellate cells contract or relax in response to a number of vasoactive substances,such as endothelin 1(ET-1),angiotensin(Angâ…¡)et al. Because HSCs play a role in both fibrosis and portal hypertension,they are currently regarded as therapeutic targets to prevent and treat liver disease. Compound Radixglycyrrhizae and Radix Salviae Miltiorrhizae(GLYSAL) is a widely used Chinese herb in anti-fibrosis therapy,several prescriptions have been considered as an effective antifiberosis drugs.