Effect Of Exercise On The Interrleukin-1 Beta (IL-1β) MRNA Expression In Muscle Tissue Of Insulin Resistant Rats

ObjectiveTo investigate the effect of high-fat diet on insulin sensitivity and the effect of swimming exercise on insulin sensitivity and Interrleukin-1(IL-1β) mRNA expression in muscle tissue of insulin resistant rats.MethodsIR rat model was created by high fatty diet for 10 weeks and evaluated with golden standard-clamp forceps technique.Three experimental groups of rats were investigated:normal group without exercise,IR group with exercise and IR group without exercise.After swimming for 4 weeks insulin sensitivity was evaluated and the Interrleukin-1 was measured.ResultsAfter swimming for 4 weeks,GIR of the IR rats was obviously higher than nonexercise IR rats(P＜0.01).After swimming for 4 weeks,the levels of IL-1βreduced markedly in IR rats compared to the IR rats non swimming(P＜0.01).ConclusionHigh-fat diet results in IR in rats.Exercise improves insulin sensitivity and reduce the level of IL-1βin IR rats created by high fatty diet.