| ObjectivesChronic ulcerative colitis is a kind of chronic colitis which is unknown aetiology and easy to recur.Its incidence rate has a increasing tendency and it has bad contribution to people's quality of daily life.Western medicine treatment below the mark,acupuncture has peculiarity and positive curative effect.In order to approach the mechanism of spleen yang-deficiency and kidney yang-deficiency syndrome of chronic ulcerative colitis which was cured by warming moxibustion therapy,prior treatment and after treatment, we has a clinical observation and detect the enteroscopy and pathological examination and blood serum interleukin-6(IL-6),and try to build a scientific experiment foundation to support the treatment.Methods60 cases come from Danjiangkou NO.1 hospital of Hubei province,they are consistent with chronic ulcerative colitis diagnostic criteria which was developed by the meeting which was held in Chengdu in 2000.According to the order in which paitients admitted to hospital,and check a random number table,all the cases are randomly divided into two groups,each group 30 cases. The observation group adopts warming moxibustion treatment,we select zhongwan,tianshu,guanyuan,zusanli,shangjuxu,shensu to treat the patient by warming moxibustion therapy,shensu,guanyuan,zusanli are treated for 10 minutes,the rest acupoints are treated for 5 minutes,a vic per day,one day resting after seven days treatment,and going on the next circulation.The control group adopts western medicine:such as sulfasalazine(SASP),1g ter in die,four times a day,30 days for one course of treatment.After the treatments of two months we will observe general effects,the main symptoms and signs of improvement,improvement in intestinal mucosal lesions and serum IL-6 levels in the changes before and after treatment.Results1.Observation group:healing rate is 53.3%,excellence rate is 23.3%, utility rate is 16.7%,inefficacy rate is 6.7%,the total effective rate was 93.3%. Control group:healing rate is 26.7%,excellence rate is 33.3%,utility rate is 13.3%,inefficacy rate is 26.7%,the total effective rate was 73.3%.Under statistical treatment,there is a significant difference(P＜0.05),efficacy of the observation group is superior to the control group.2.In the main symptoms and signs of improvement,compared with pretherapy,the observation group's improvements are significant after the treatment,and there is a significant difference(P＜0.05),after the statistical treatment;although the symptoms of the control group have improved,but the efficacy of the treatment is not significantly,statistical analysis showed there was significant difference(P＜0.05).3.In the improvements of intestinal mucosal lesions,compared with pretherapy,the observation group and control group after treatment are improved and there were significantly different(P＜0.05);however,the treatment group to improve the situation was even more pronounced compared with the control group,with statistical analysis,there are significant differences(P＜0.05). 4.In the changes of content of the the peripheral blood IL-6,compared with the pretherapy the two groups were lower after the treatment,and there is a significant different(P＜0.05);group comparation,the observation group score reduced more significantly,the two groups have significant difference(P＜0.05).Conclusions1.Both the warm moxibustion therapy and the oral SASP can improve symptoms in patients with signs and pathological changes of intestinal mucosa, warm moxibustion group is superior in this combination effect to the SASP group.2.Both the warm moxibustion therapy and the oral SASP can reduce the peripheral blood IL-6 content,warm moxibustion group is superior in this aspect to the the SASP tablet group.3.Warming moxibustion can depress IL-6 significantly patients of spleen yang-deficiency and kidney yang-deficiency syndrome of ulcerative colitis, suggesting that warming moxibustion might mild immune system to treat spleen yang-deficiency and kidney yang-deficiency syndrome of ulcerative colitis. |
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