| PurposeIn order to explore the epidemiology of fungal infection in respiratory tract and how to do early diagnosis in children, so that clinicians can reduce missed or misdiagnosed cases, and children can receive medical treatment as soon as possible.MethodsRetrospective analysis the 63 cases of fungal infections in respiratory tract which diagnosed by clinical or suspected in Children's Hospital affiliated to Zhejiang University. To discuss the fungus species and risk factors by list analyzing the incidence of fungal infections and related diseases, and to discuss the correlations between infections and age, season, basic disease, hospital stay, course and treatment.ResultsFungal infections in respiratory tract in children had the major pathogen—Candida, including Candida albicans (39 cases);Candida glabrata (14cases); Candida tropicalis (10cases).Fungal infections in respiratory tract in children occurred in each section of ages. The basic diseases of these patients include respiratory diseases (24 cases), blood system diseases (14 cases), cardiovascular system (8 cases), nervous system (4 cases), 13cases with other diseases. The occurrence of fungal infection is related with using a variety of antibiotics, the application of glucocorticoid, tracheotomy and intubation, surgery, and patients with blood system diseases.ConclusionIn this paper, we did epidemiological survey of fungal infection in Children's Hospital affiliated to Zhejiang University, and found that Candida albicans was still the major pathogen of fungal infections. Through the analysis of the relevant factors, we considered that fungal infections of the respiratory tract were mainly happened in children with respiratory system or blood system diseases, especially for premature infants and children in ICU. Its risk factors include widely using of broad-spectrum antibiotics, corticosteroids and immunosuppressive agents, using ventilator in ICU patients, as well as the promotion of surgery, which is similar to other studies at home and abroad. From this paper, we provide a basis and reference for clinicians to improve awareness of fungal infections, make early diagnosis and early treatment. In addition, because the cases were all Candida infections, and Candida albicans infections are the main strain, fluconazole is still as a drug of first choice used on clinical prevention or treatment. In recent years, non-Candida albicans infections have been upward trend, itraconazole has broad antibacterial spectrum, and its side effects is not significant difference between fluconazole, so it can be used as the first choice for the treatment of deep fungal infection. |
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