| Fluoride is an essential element for human body, but excess intake of fluoride in human body can mainlycause damage of teeth and bone. Many scholars paid close attention to screening risks factors of high fluoride in organism and it is very essential to indentify the primary sensitive indicatrix for forecasting fluoride bone injury. Experimental study and field research were used to explore influencing factors for fluoride concentration in organism and search for early sensitive index for fluoride bone injury. The purpose of the study is to provide early, sensitive, economical and practical indexes for the people exposed to fluoride.Part I Analysis of about fluoride burden(serum fluoride , urine fluoride)and influnencing factorsObjective This study is cohort study to examine fluoride burden state among male workers whom were from different aluminiun factory workshop with five yeare length of service, And analyze association of five risk factors-Workmen's age, length of service, smoking, drinking and workshop.Method and Content 212 male subjects from an aluminiun factory in HUBEI province were selected, whom come from institution ,aluminum pole workshop and potroom . 50 male subjects without exposure history of industry fluoride (age25～45) from the same region were recruited. The subjects with the diseases of liver and kidney what influence fluoride absorption and egestion were excluded. The subjects who take medicine hormone in three month were excluded. Evaluate atmosphere fluoride of workshops and town, serum fluoride and urine fluoride of objects. Observe five risk factors-Workmen's age, length of service, smoking, drinking and workshop.Results The atmosphere fluoride of aluminum pole workshop and potroom(2.31±1.01 mg/m3; 0.26±0.10 mg/m3) is more than atmosphere fluoride of control group(0.10±0.05 mg/m3)with a significant difference(P<0.01). The urine fluoride and serum fluoride of potroom (0.22±0.06 mg/L;7.96±8.41 mg/L) is more than urine fluoride and serum fluoride of control group(0.16±0.03 mg/L;2.19±1.02 mg/L)with a significant difference(P<0.01). The urine fluoride and serum fluoride of aluminum pole workshop (0.22±0.07mg/L;4.39±5.21mg/L)is more than urine fluoride and serum fluoride of control group(0.16±0.03 mg/L;2.19±1.02 mg/L)with a significant difference(P<0.01). The urine fluoride and serum fluoride of the high age group(0.22±0.08mg/L;5.10±4.01mg/L)is more than urine fluoride and serum fluoride of control group(0.19±0.05 mg/L;4.27±4.92 mg/L)with a significant difference(P<0.05). The urine fluoride and serum fluoride of the long length of service group(0.22±0.07mg/L;6.01±7.05mg/L)is more than urine fluoride and serum fluoride of control group(0.20±0.06mg/L;3.22±4.32mg/L)with a significant difference(P<0.05).The urine fluoride and serum fluoride of the quaque smoking group(0.22±0.04mg/L;5.73±4.92mg/L)is more than urine fluoride and serum fluoride of control group(0.19±0.05mg/L;4.33±3.96mg/L)with a significant difference(P<0.05). The urine fluoride and serum fluoride of all drinking groups without a significant difference(P>0.05).Conclusions Urine fluoride and serum fluoride of object whom come from potroom and aluminum pole workshop more than the control group. The factors- Workmen's age, length of service, smoking and workshop influence urin fluoride and serum fluoride with a significant difference. The risk factors-drinking influence urin fluoride and serum fluoride without a significant difference.we cannot think. The factor-drinking is a risk factor what influence urine fluoride and serum fluoride.Part II Analysis about fluoride burden and serum osteocalcin, serum calcitioninObjective This study is to investigate the early indexes of industry bone injury by examine serum osteocalcin and serum calcitonin, to explain the mechanism of action of serum osteocalcin and serum calcitonin about industry bone injury. We will discover high-risk group and evaluate risk-health by examine serum osteocalcin and serum calcitonin.so that we will focal point safeguard the crowd whom with high risk-health.Method and Content We group 90 hapto-fluoride subjects into three groups according to urine fluoride and serum fluoride, base on the analysis of urine fluoride and serum fluoride in part I: low fluoride burden group(urine fluoride≤2.0 mg/L and serum fluoride≤0.17mg/L); midst fluoride burden group(2.0 mg/L< urine fluoride≤4.0 mg/L and 0.17mg/L4.0 mg/L and serum fluoride>0.20mg/L)。we examine serum osteocalcin and serum calcitonin by radio-immunity method.Results The serum osteocalcin and serum calcitonin of high fluoride burden group (7.37±2.18ng/mL;84.11±25.45 pg/mL)is more than serum osteocalcin and serum calcitonin of control group(4.87±1.85ng/mL;59.96±21.16pg/mL)with a significant difference(P<0.01). The serum osteocalcin and serum calcitonin of midst fluoride burden group (5.99±2.03ng/mL;71.92±13.29 pg/mL)is more than serum osteocalcin and serum calcitonin of control group(4.87±1.85ng/mL;59.96±21.16pg/mL)with a significant difference(P<0.05). The serum osteocalcin and serum calcitonin of high fluoride burden group (7.37±2.18ng/mL;84.11±25.45 pg/mL)is more than serum osteocalcin and serum calcitonin of normal reference group(5.40±3.30ng/mL;72.00±7.00pg/mL)with a significant difference(P<0.01).Conclusions The serum osteocalcin and serum calcitonin of all fluoride burden groups with a significant difference, and compare with serum osteocalcin and serum calcitonin of normal reference group with a significant difference.So we think that the serum osteocalcin and serum calcitonin are early diagnosis reference indexes of industry bone injury.
|
PDF Full Text Request