| Sevoflurane is a new halogen-containing volatile anesthetic, with the blood/gas partition coefficient of 0.63 and the oil/gas partition coefficient of 42. Sevoflurane has been widely used in clinical anesthesia due to such advantages as making patients quickly induced and awaken, less airway irritation and circulation depression, certain muscle-relaxing effect, easily controlled, low solubility, rapidly absorbed and eliminated, etc. In recent years, organ protective effects of sevoflurane, especially myocardial protection, have received considerable attention. The experiment results have indicated that sevoflurane has certain myocardial protection effects and the protective mechanism is similar to that of ischemic preconditioning. It can activate the ATP sensitive potassium channels and then prevent calcium overload. Therefore, energy metabolism is decreasing and the productions of oxygen free radicals are reduced. Furthermore, sevoflurane could protect the myocardium through inhibiting neutrophil adhesion and platelet aggregation. Comparing to other volatile anesthetics, sevoflurane can provide better hemodynamic stability.Sevoflurane in clinical concentration can preferentially increase blood flow of coronary collateral vessels, increase coronary reserve and decrease myocardial oxygen consumption. It affects cardiac function slightly and this advantage is more obvious in high concentration. Therefore, sevoflurane can play a role in myocardial protection during anesthesia period.In addition, sevoflurane has little effect on cardiac conduction system.Above all , sevoflurane is especially suitable for those patients complicated with heart diseases.The limitation we must pay attention to is that sevoflurane can prolong the Q-T and Q-Tc interval, so it can not used in the patients with prolonged Q-T interval syndrome. This article reviews the development of mechanism of myocardial protection of sevoflurane and its influence on cardiovascular system. |
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