Advancement Of PPARγ Agonist In The Treatment And Prevention Of Cerebral Infarction

peroxisome proliferate activated receptor gamma(PPARγ)is a new concept. It is a ligand-activited transcription factor which belongs to nuclear receptor superfamily. It can transmit peroxisome growing effect. It distributes generally and participates in many biological effects, such as enhancing organism sensitivity to insulin, controlling insulin resistance; inhibiting Inflammatory reaction; influencing tumour, fatness and so on. Inflammatory reaction is an important damage mechanism in no matter cerebral infarction or artherosclerosis. On the basis of the above mechanism, we conclude that PPARγagonist can reduce infarction volume, prevent artherosclerosis, accommodate glycometabolism. Many related experiments authenticate that inference. Moreover, whether hyperglycemia or artherosclerosis is an independent risk factor of cerebral infarction. Accordingly, PPARγagonist is not only the treatment of hyperglycemia or artherosclerosis, but also the preservation of cerebral infarction, the most significant is that it may have the pretreatment for cerebral infarction. PPARγagonist is an original trend in treatment and prevention of cerebral infarction.