A Case Report Of Endocervical Adenocarcinoma With Hydrometra

Objective: To summarize some clinical characteristics about increased watery vaginal discharge suspected hydrometra by imaging. Earlier diagnosis is sometimes difficult, as biopsy specimen might only contain the sample of superficial part of the tumor. The physician should pay attention for the possible existence of endocervical (mucinous) adenocarcinoma in a patients with rapid reaccumulation of hydrometra, when clinically suspected uterine malignancy and failed to confirm diagnosis in biopsy.Methods: Analyses characteristics of a case of increased watery vaginal discharge and hydrometra suspected by imaging. And through analysis of its clinical relation to the diagnosis and treatment by cervical screening, histology, pathogenesis of endocervical adenocarcinoma .Results: The pathological study of surgical specimens revealed mucinous adenocarcinoma, which was located on the proximal area of cervix. Adjacent to carcinoma tissue, was located lobular endocervical glandular hyperplasia (LEGH) which did not involve in the transformation zone. Human papillomavirus (HPV) was not detected using immunohistochemistry and ISH ( in situ hybridization) in either LEGH or adenocaercinoma components.Conclusion: LEGH may represent a precursor of endocervical (mucinous) adenocarcinoma independent to non-HPV infection. So surgical removal should be considered for LEGH growth beyond a certain size.