Synthesis Of The Analogues Of High Fatty Acids And Their Anti-Tumor Activities

Objective: To synthesize the analogues of high fatty acids by structural modification. To select anti-tumor active compounds through the anti-tumor testing in vitro. To study those compounds on their anti-tumor effect and dose-effect relationship in vivo.Method: 1. To synthesize the analogues of high fatty acids by structural modification and elucidate their structures. 2. Anti-tumor activities in vitro selection: Choose one tongue cancer, ovarian cancer and other cells, flow cytometry application of compounds on the destruction of tumor cells, the activity of compounds in the screening. 3. Anti-tumor effect in vivo: S180 cells were to Kunming mice, a mouse ascites tumor model S180, research compounds in anti-tumor effects, study treatment group to extend the life of the rate and weight Change, and research carried out dose-effect relationship in vivo .Results: 1. Eight designed compounds were synthesized and structural identified. 2. Three compounds MDH332, MDH341 and MDH342 have obvious anti-cancer active to cancer cells in vitro, MDH341 is strongest. 3. Further proof to do in vivo, MDH341 can extend the survival time of mice ascites tumor model S180.Conclusion: In vitro proof, MDH332, MDH341, MDH342 in the anti-tumor has a certain prospect, MDH341 is strongest; in vivo proof , MDH341 can extend the survival time of mice ascites tumor model S180.