Clinical Research On The Protective Effect Of Magnesium Isoglycyrrhizinate On Liver Function After Liver Resection

Objective:To observe the concentration of magnesium isoglycyrrhizinate in portal vein and its impact on serum transaminase after liver resection.Materials and Methods:64 cases with liver resection were randomly divided into test and control groups.The test group were given magnesium isoglycyrrhizinate 150mg at the beginning of the operation.Portal vein and peripheral venous blood of patients were taken after 1 hour of drug use and the high-performance liquid chromatography-UV detection method was used to determine the drug concentration in plasma.The drug was used for 7 days after the operation.The control group were not given the drug.ALT,AST,TBIL,DBIL,GGT and ALP levels of fasting venous serum were determined before operation and on the day 1,3,7 after operation.Results:The concentration of magnesium isoglycyrrhizinate in portal vein blood was significantly higher than in peripheral vein blood in patients with liver resection(close to 2 times).Postoperative ALT and AST of the test group were significantly lower than of the control group.To the 7th postoperative day,the serum ALT levels of most of the patients in test group returned to normal(64.5%).Adverse reactions such as pseudohyperaldosteronism did not appear in the process of using the drug.No complications after liver resection increased.Conclusions:There has a higher blood concentration of magnesium isoglycyrrhizinate in portal vein after using the drug in patients with liver resection.Magnesium isoglycyrrhizinate can lower the rapid increase of serum transaminase after hepatectomy and reduce complications and is suitable for the use of perioperation of liver.