Structoglceride For Total Parenteral Nutrition Clinical Observation Of Safety

Objective:By observing structoglceride in the clinical study of total parenteral nutrition support of the application,and evaluation of structoglceride in the clinical application of the safety and value.Methods:First Hospital of Shanxi Medical University,general surgery 31 cases of patients(NRS-2002score≥3分) who can not eat from June,2008 to November,2008o,Excluded Abnormal lipid metabolism,diabetes and other metabolic diseases(hyperthyroidism / hypothyroidism,adrenal gland,cortical dysfunction),the liver and kidney dysfunction,and pregnancy,breast-feeding women.According to the actual situation in patients with nutritional risk score line after TPN,the structure of fat emulsion with fat emulsion.To glucose,fat emulsion,amino acids and other nutrients into the mixed and the preparation of "all-in-one"(TNA) after the infusion of nutrient solution,Period of nutritional support to the fifth day of the first day。Observed during treatment of patients every day whether or not allergy, nausea,vomiting,abdominal pain,bloating,diarrhea and other symptoms.With TPN in the day before,TPN after the first day of the third day,the fifth day of taking the early morning fasting blood 6:00,Detection of lipids,cholesterol,total protein,albumin,prealbumin,urea nitrogen, neutrophils,monocytes,lymphocytes.Results:1.Clinical observation of the patients studied there was no obvious adverse reactions,No case of nutrition support-related complications,A very small number of patients have symptoms of abdominal discomfort after adjusting the speed of transfusing to improve.2.Triglyceride,cholesterol and blood urea nitrogen in the days after the first indicators of nutritional support of nutritional support is lower than before(p≤0.05),Nutritional support after the first,third and five of these indicators did not change significantly,fluctuations in the normal range.3.Nutrition support process on the nutritional indicators were tested,After the first day of TPN total protein,albumin,prealbumin has declined,and then gradually increase their level,the fifth day of detection of the protein targets are higher than pre-TPN,and TPN was significantly higher than the first day after(p≤0.05). 4.Changes in the number of blood cells:the number of lymphocytes than the fifth day before the increase in nutrition(p≤0.05),And the other the number of leukocytes between the before and after the normal fluctuations.Conclusion:1.The structoglceride on plasma lipid levels had no significant effect.2.Containing the structoglceride of the TPN in the promotion of protein synthesis has an important role.3.The structoglceride on renal function and no significant effect on immune function.4.The structoglceride in the clinical application of better security,but also has a therapeutic effect.