Clinical Research Of Gui Long-Pullet On Diabetic Patients With Lower Limb Angiopathies

Background:Lower Extremity Arterial Disease in Diabetes Patients is symptom complex,including claudication,pain,anaesthesia and sense of heaviness, and which is the disease of chronic obliterative atherosclerotic.The Diabetic patients who incorporate Lower Extremity Arterial have more chances than no DM patients.Also the time of happening will ten years advance in DM.Owing to the course of disease prolonging and pathogenetic condition aggravates, blockage and angiostegnosis will appear,the amputation is the finally result. Not only LEADDP makes society and patients have serious burden of economy,but also to influence they lives and results a serious waste of medical resources. So more and more epidemiologists,endocrinologists,clinic pxperts and pharmacologists began to study and research the curing LEADDP early.Objective:To research the mechanism of Gut Long-Pullet curing LEADDP,and to observe the ABI,CRP,DD,CDU,blood fat before and after in the treatment. To research the effective and physiological mechanism of Gui Long-Pullet,in result the clinical will has based on it.Methods:Accord to the diagnostic code of China Guideline for Type 2 Diabetes 2007,the DM will be checked up the ABI and CDU,which have PVD and to accord with the TCM syndrome differentitation(excluding the syndrom of heat due to deficiency of yin group) were randomly divided into two groups.The patients is totally 68,who came from hospital and out-patient clinic.Control group(34 cases) were given Cilostazol(50mg Bid).Treatment group(34 cases) were given Gui Long-Pullet.After treatment for 12 weeks,observing and comparing the two groups LEADDP symptom and the blood fat,CRP,DD,ABI,CDU between treatment before and later.We compare the effective rate of the two groups the medicine which they given and result in whether the Gui Long-Pullet has effcets in curing LEADDP.Results:The claudication,pain,anaesthesia and sense of heaviness symptom score of the two groups patients,there were significant differences between the two groups before treatment and after treatment(P＜0.05);after treatment, treatment group is prefer to control group in the improvement of the ABI,CDU,CRP,TC and TRIG(P＜0.05).In patients of Gui Long-Pullet,prior treatment also surpass post-treatment(P＜0.O5);The effective rate and the proportion of patients still choosing the medicine which they were given of treatment group is also more high than control group.Conclusion:Gui Long-Pullet can improve claudication,pain,anaesthesia and sense of heaviness,ameliorate the blood viscidity and coagulate by the TC and TRIG,reduce the CRP to mitigate the inflammatory reaction,and improve the ABI and CDU quickly and manifestly.Gui Long-Pullet is an effective method to treat LEADDP.But it has no effect to improve DD to cure the deep vein thrombus of lower limb.Characteristics and new ideas:Making use of contemporary diagnosis diplomacy, dialectical standard of TCM,standard of curative effect judgement and scientific study method and deploying experiment which Gui Long-Pullet randomly treats LEADDP prospectively authenticate its therapeutic effect.And approach the influence to ABI,to confirm ABI is an effective screening early and an index of discriminating therapeutic effect in LEADDP.We make use of the methods which includs symptom intergral and ABI,CDU and inflammatory factor.