An Animal Experiment On The Effect Of NHAG And PLLA And CF Which Is Used To Cure The Bone Damage

Objective: to investigate osteogenetic ability and biological response of three kinds of biomaterial---- nHAC/PLLA/CF; comparing difference of osteogenetic ability and biodegradation between three different biomaterial thereby can we reveal some factors in related to osteogenesis ability and biodegradation of three biomaterial acting as bone replacement.Method: 6 New Zealand rabbits were offer by the animal laboratory of Jinlin Universtity .They were 6-8 weeks old that weigh 1.5-2.0Kg.There were no difference between male or female.Then they were divided into two groups by chance. The right radial bone were embed the material of nHAC/PLLA/CF . The left radial bone :there were two blanks for comparison and four for nHAC/PLLA/CF. Specimens harvested in4w and 8w postoperation were further assessed on the two groups. Specimens harvested on 3 rabbits every time. Sampling should include the material and the normal bone around 1cm.Result : 1. Use X line to check Na rice Qian radicle apatite/ the original gum /gather-L-lactic acid chitin fiber compound material set and the Na rice Qian radicle apatite/gather-L-lactic acid set at all show that the bone's break to carry for 4 weeks inside formed a high definition bone organization shadow. There was a hint to have the bone organization of calcify. The Na rice Qian radicle apatite / the original gum /gather-L-lactic acid chitin fiber compound material set bone link compare the Na rice Qian radicle apatite/gather-the L-lactic acid set is obvious, while the matched control then go ossification which is not conjunction. In the 8 wees, the Na rice Qian radicle apatite/ the original gum /gather-L-lactic acid/chitin fiber compound the material set attain a bone to heal, the Na rice Qian radicle apatite/gather-the L-lactic acid set Be basic to attain a bone to heal, while the matched control is still a bone not connecting .2.The histology checks the Na rice Qian radicle apatite/the original gum /gather-L-lactic acid/chitin fiber compound material set and the Na rice Qian radicle apatite/gather-L-lactic acid set at 4 weeks. The ossification conjunction of the specimen can be seen, and among them the Na rice Qian radicle apatite/ the original gum /gather-L-lactic acid/chitin fiber compound the material set is more obviously, while the matched group's ossification conjunction was not obvious.8 weeks later,the Na rice Qian radicle apatite/ the original gum /gather-L-lactic acid/chitin fiber sugar compound material set of bone's turning to knot the soft radicle quality in the stanza a basic completion bone have already turned process, the physical volume of bone cell is smaller. The bone turns knot stanza to around have the fine fiber organization the overlay. The Na rice Qian radicle apatite/|gather-the bone of the L-lactic acid material set turn to knot the soft radicle quality bone in the stanza to turn process not yet finished and only see a little amount bone cell. But the matched groups are not connected.Conclusion: the Na rice Qian radicle apatite/ the original gum /gather-L-lactic acid/chitin fiber compound the material has a good repair bone defection and damage ability, also own better biology effect in the meantime. They can lie in curing in the bone defection and damage and act for from the body bone.