The Research Of The Relationship Between Coronary Artery Disease And Depression And The Impact Of Depression On The Occurrence And Development Of Coronary Artery Disease

Coronary artery disease (CAD)includes coronary atherosclerotic heart disease, coronary artery spasm and coronary artery functional changes. Coronary CAD is one of the most common causes of death in the world. Along with the aging of population and enhancement of living standards, the morbidity and mortality of CAD is growing year by year in our country. The exact etiopathogenisis of CAD is still not completely clear. Many investigations indicated that CAD is the result of multiple factors including blood fat abnormality, hypertension, diabetes, smoking, infaust life style, alcohol intake, inflammatory reaction, hyperuricacidemia, hyperhomocysteinemia, age, gender and so on. Recent researches abroad discovered that CAD patients are easily to affiliated with psychologic obstacle such as low emotion, energy decrease, low self-evaluation, giving us a cue that depression may be an independent risk factor and play a significant role in the occurrence and development of CAD.Depression is a kind of mood disorder characterized with significant and persistent emotion step down, decrease of locomotor activity, and slow thinking and cognition function. Depression seriously curses the life and work of patients, and bring heavy burden to their families and our society.Recent years, more and more attentions are paid to psychological and behavior changes of CAD patients, as well as the impacts of depression to CAD development. The relationship of depression and CAD is complex and not exactly identified. The two may influence facilitate each other. Depression increases the risk of CAD and promotes the development of CAD. Patients with CAD have a higher risk to depression than health people, and the occurrence and development of CAD may result in depression.Objective: To approach the relationship of CAD and depression, and the influence of depression on the CAD occurrence and development.Methods: The sample of CAD group are 80 patients with CHD who at least have 1 coronary artery narrowed≥50% during Sep.2006 to Dec.2008, 38 male and 42 female,average(63.1±10.3) years old, and 78 health persons as control group at the same time, 40 male, 38 female, average(62.7±10.2)years old. Make investigations to the two groups with SDS and BDI, and analyse the morbidity and degree of depression. Divide the CAD group into 2 subsets: A: CAD affiliated with major depression; B: CAD affiliated with slight or no depression. Make dynamic electrocardiogram for patients in two subsets with TLC 4000 electrocardiograph, study the incidence of arrhythmia heart rate variability and average heart rate.We also detect the levels of blood-fasting sugar and blood fat of two subsets patients with American BECKMAN SYNCHRON LX20 automatic biochemistry analyzer.Results:①The morbidity of depression in patients with CAD is significantly higher than that of control group(P<0.05).②Patients of A subset have a higher incidence of arrhythmia, compared to B subset (P<0.05).③The heart rate variability is lower while the average heart rate is faster in A subset than B subset (P<0.05).④The levels of blood-fasting sugar and blood fat of A subset are significantly higher than that of B subset (P<0.05).Conclusion: Patients with CAD are at a high risk of depression, and depression aggravates the condition of patients with CAD. It demonstrates that depression may be an independent risk factor of CAD, and play significant role in the development of CAD.