Synthesis And Antimicrobial Activities Of Compounds Containing Indanone Skeleton

A large number of compounds containing indanone skeleton showed good biological activity, such as anti-cancer, anti-inflammatory / anti-allergic, anti-cardiovascular sclerosis, bactericidal, weeding and so on. Indenopyridines and indenoquinolines were used in medicine and pesticide widely. In order to further enlarge the application of indanone derivatives, we design and synthesize some indanone derivatives and evaluate their antimicrobial activities.In the Chapterâ…¡, four 1, 3-indandiones have been synthesized. The best reaction conditions have been optimized by a series of tests. The structures of the synthetic compounds were confirmed by ~1H-NMR and IR spectra. In the Chapterâ…¢, thirteen 2-arylidene-l, 3-indandiones and ten 2-arylidene-4-nitro- 1, 3- indandiones have been synthesized, of which ten are new compounds. The structures of the synthetic compounds were confirmed by ~1H-NMR and IR spectra. In the Chapterâ…£, seven 3-phenylamino-1H-inden-1-one compounds have been synthesized, of which four are new compounds. The structures of the synthetic compounds were confirmed by ~1H-NMR and IR spectra. In the Chapterâ…¤, four indenodihydropyridines have been synthesized, of which three are new compounds. The structures of the synthetic compounds were confirmed by ~1H-NMR and IR spectra. In the Chapterâ…¥, the antibacterial activities of the synthetic compounds were studied. Most of 2-arylidene-4-nitro- 1, 3- indandiones compounds showed a certain degree of antibacterial activity. 2-arylidene-4-nitro- 1, 3- indandiones is a potential antibacterial agent. Three 3-phenylamino-1H-inden-l-one derivatives showed antibacterial activity, two of which have the strong antibacterial activity. It is worth further study. In the Chapterâ…¦, a preliminary structure- activity relationship of indene derivatives was discussed.