| Objective To investigate the effects of autoantibodies againstα1 -adrenergic receptor on cardiac remodeling in patients with hypertension.Methods 553 patients with hypertension in our hospital whose autoantibodies againstα1 -adrenergic receptor in the serum was detected by ELISA and recorded results of echocardiography. By multiple logistic regressions, the risk factors were analyzed on left ventricular enlargement of hypertension.Results The percentage of autoantibodies againstα1 -adrenergic receptor positive was 32.3 %( 179/553). The mean age, course of disease, heart rate and proteinuria incidence rate of the positive group were significantly higher than those of the negative group. There were significant difference between the positive group and negative group on the ratio of left atrial (53.6%, 44.3%, respectively) enlargement (P<0.05) and left ventricular (12.8%, 6.1%, respectively) enlargement (P <0.01), and there were no significant differences in right atrial dimension and right ventricular diastolic dimension and interventricular septal thickness and left ventricular ejection fraction between these two groups. The result of regression analysis demonstrated that 4 risk factors were related to left ventricular enlargement, including male, course of disease, heart rate and autoantibodies againstα1 -adrenergic receptor in the serum (all P<0.05).Conclusions The autoantibodies againstα1 -adrenergic receptor have some relationship with left ventricular enlargement and may be an important factor in resulting in cardiac remodeling of hypertension. Patients with againstα1 -adrenergic receptor positive was significant to predict left ventricular remodeling.
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