Studies On The Hydroxyapatite Orbital Implants Fibrovascularization With MRI

Objective: To evaluate the clinical worth of application by investigating the characteristic of imaging in rabbits and human hydroxyapatite orbital implants fibrovascularization with MRI and exploring the relation between time and vascularization of the orbital implants.Methods: 30 New Zealand white rabbits'right orbits with the same surgery procedure were divided randomly into 6 groups. At 1 week, and next six weeks postoperatively, imaging in rabbits hydroxyapatite orbital implants fibrovascularization were measured with MRI, and VE/VHA were calculated. One of groups'hydroxyapatite orbital implants were observed by HE stain.; Whereas, 15 eyes of 15 patients with the same surgery procedure, at 1 month, and next seven months postoperatively, imaging in humen hydroxyapatite orbital implants fibrovascularization were measured with MRI, and VE/VHA were calculated.Results: Before the 4th week, the average VE/VHA of the HA orbital implants in rabbits added up weekly, while the average VE/VHA of 5w and 6w are almost the same, all the HA orbital implants had accomplished fibrovascularization at the 4th week; To patients, before the 6th month, the average VE/VHA of the HA orbital implants added up weekly, but the average VE/VHA of 6th and 7th month are almost identical.Conclusions: MRI is a way to detect hydroxyapatite orbital implants fibrovascularization; 12mm HA orbital implants in rabbits had accomplished fibrovascularization at the 4th week; To patient, 20mm HA orbital implants had accomplished fibrovascularization at the 6th month.