Synthesis Of Two New Types Of Polyanhydrides And Application For Drug Release

As a type of new biodegradable material, polyanhydrides have many special advantages. For example, polyanhydrides are prepared from easily available low cost resources and are generally considerable as safe dicarboxylic acids building blocks, many are body constituents or metabolites. Polyanhydrides can be sterilized by terminalγ-irradiation with minimal effect on polymer properties. But the most advantageous respect is that polyanhydrides can be accordingly manipulated to release bioactive agents at a predictable rate for periods of weeks. This character only belongs to polyanhydrides and enable the process of drug release according to zero-dynamic character. In this thesis, the classification, microstructure, characterization and control-release behavior of polyanhydride were reviewed, and the progress in co-polyanhydride as control-release materials were emphasized.Seeking for novel polyanhydride with desired biodegradability in vivo, which may be used for the delivery of hydrophibic drugs, we synthesized four different new monomers (benzyl citric acid (BCA), 4-(4-carbxypropoxy) benzoic acid (CPB), 2-(4-carbxypropoxy) benzoic acid (CPB) and 4, 4'-[1, 4-butanediylbic(oxy)]bisbenzoic acid (bdBA)), and relative four new types of copolyanhydrides from copolymerization of above four monomer with sebacic acid (P[BCA-SA], P[4-CPB-SA], P[2-CPB-SA] and P[bdBA-SA]). The chemical structure were characterized by IR, 1H NMR and GPC techniques, the drug release behavior of these copylymers were investigated.The degradation speed of those two types of polyanhydrides is very fast, and the properties of drug release of those new polyanhydrides is excellent compare to most reported polyanhydrides. These polyanhydrides have a higher zero-dynamics rario in release time, this result is better than those reported before. We hope adjusting the speed of drug release by changing the rario of monomer in copolymers. The experimental result shows that the speed of sustaining-release of all polyanhydrides is adjustable, poly [BCA-SA] release ciprofloxacin hydrochloride completely during 6-23 days; poly[2-CPB-SA] is during 24-34 days; poly[4-CPB-SA] is during 24-34 days, and poly[bdBA-SA] is during 27-31 days. However, poly[bdBA-SA] is expectable, its speed of drug release change little. These experimental results showed that these copolymer have a potential application value as biomaterials for drug control releasing .